(2S)-2-cyclopropyl-N-[[(4R)-4-cyclopropyl-2,5-dioxo-imidazolidin-4-yl]methyl]-3-[4-(trifluoromethyl)phenyl]propanamide

Base Information

Chemical Name:(2S)-2-cyclopropyl-N-[[(4R)-4-cyclopropyl-2,5-dioxo-imidazolidin-4-yl]methyl]-3-[4-(trifluoromethyl)phenyl]propanamide
CAS No.:1607004-34-1
Molecular Formula:C₂₀H₂₂F₃N₃O₃
Molecular Weight:409.408
Hs Code.:

Synonyms:(2S)-2-cyclopropyl-N-[[(4R)-4-cyclopropyl-2,5-dioxo-imidazolidin-4-yl]methyl]-3-[4-(trifluoromethyl)phenyl]propanamide

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Chemical Property of (2S)-2-cyclopropyl-N-[[(4R)-4-cyclopropyl-2,5-dioxo-imidazolidin-4-yl]methyl]-3-[4-(trifluoromethyl)phenyl]propanamide

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Technology Process of (2S)-2-cyclopropyl-N-[[(4R)-4-cyclopropyl-2,5-dioxo-imidazolidin-4-yl]methyl]-3-[4-(trifluoromethyl)phenyl]propanamide

There total 5 articles about (2S)-2-cyclopropyl-N-[[(4R)-4-cyclopropyl-2,5-dioxo-imidazolidin-4-yl]methyl]-3-[4-(trifluoromethyl)phenyl]propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: (5R)-5-(aminomethyl)-5-cyclopropyl-imidazolidine-2,4-dione hydrochloride

: (S)-2-cyclopropyl-3-(4-(trifluoromethyl)phenyl)propanoic acid

: 1607004-34-1
(2S)-2-cyclopropyl-N-[[(4R)-4-cyclopropyl-2,5-dioxo-imidazolidin-4-yl]methyl]-3-[4-(trifluoromethyl)phenyl]propanamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 48h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.7b00650

Reference yield:

: 1000053-98-4
(S)-4-benzyl-3-(2-cyclopropyl-acetyl)-oxazolidin-2-one

: 1607004-34-1
(2S)-2-cyclopropyl-N-[[(4R)-4-cyclopropyl-2,5-dioxo-imidazolidin-4-yl]methyl]-3-[4-(trifluoromethyl)phenyl]propanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / -78 - 70 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: dihydrogen peroxide; lithium hydroxide / tetrahydrofuran; water / 2 h / 0 °C

3.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / 48 h / 20 °C / Inert atmosphere

With dihydrogen peroxide; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; lithium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.7b00650

Reference yield:

: C₂₃H₂₂F₃NO₃

: 1607004-34-1
(2S)-2-cyclopropyl-N-[[(4R)-4-cyclopropyl-2,5-dioxo-imidazolidin-4-yl]methyl]-3-[4-(trifluoromethyl)phenyl]propanamide

Guidance literature:: Multi-step reaction with 2 steps

1: dihydrogen peroxide; lithium hydroxide / tetrahydrofuran; water / 2 h / 0 °C

2: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane; N,N-dimethyl-formamide / 48 h / 20 °C / Inert atmosphere

With dihydrogen peroxide; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; lithium hydroxide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.7b00650