4-(2-azidoethyl)-7-(3-chlorophenyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one

Base Information

Chemical Name:4-(2-azidoethyl)-7-(3-chlorophenyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one
CAS No.:1429501-01-8
Molecular Formula:C₁₅H₁₄ClN₅O
Molecular Weight:315.762
Hs Code.:

Synonyms:4-(2-azidoethyl)-7-(3-chlorophenyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one

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Chemical Property of 4-(2-azidoethyl)-7-(3-chlorophenyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one

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Technology Process of 4-(2-azidoethyl)-7-(3-chlorophenyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one

There total 6 articles about 4-(2-azidoethyl)-7-(3-chlorophenyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1429501-00-7
2-[1-oxo-7-(3-chlorophenyl)-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl]ethyl methanesulfonate

: 1429501-01-8
4-(2-azidoethyl)-7-(3-chlorophenyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one

Guidance literature:: With sodium azide; In N,N-dimethyl-formamide; acetonitrile; at 80 ℃; for 18h;

Reference yield:

: 63503-60-6
3-chlorophenylboronic acid

: 1429501-01-8
4-(2-azidoethyl)-7-(3-chlorophenyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: caesium carbonate / water; dichloromethane

2: lithium hydroxide

3: N-ethyl-N,N-diisopropylamine; sodium hydrogencarbonate / tetrahydrofuran; ethyl acetate

4: triethanolamine

5: sodium azide / N,N-dimethyl-formamide; acetonitrile; diethyl ether

With lithium hydroxide; sodium azide; triethanolamine; sodium hydrogencarbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; diethyl ether; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1429500-38-8
ethyl [7-(3-chlorophenyl)-1-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-4-yl]acetate

: 1429501-01-8
4-(2-azidoethyl)-7-(3-chlorophenyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: lithium hydroxide

2: N-ethyl-N,N-diisopropylamine; sodium hydrogencarbonate / tetrahydrofuran; ethyl acetate

3: triethanolamine

4: sodium azide / N,N-dimethyl-formamide; acetonitrile; diethyl ether

With lithium hydroxide; sodium azide; triethanolamine; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; diethyl ether; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;