(S)-4--3-<<(1,1-dimethylethyl)diphenylsilyl>oxy>butanoic acid methyl ester

Base Information

• Chemical Name: (S)-4--3-<<(1,1-dimethylethyl)diphenylsilyl>oxy>butanoic acid methyl ester
• CAS No.: 119900-72-0
• Molecular Formula: C₂₇H₄₁O₆PSi
• Molecular Weight: 520.678

Synonyms:(S)-4--3-<<(1,1-dimethylethyl)diphenylsilyl>oxy>butanoic acid methyl ester

Chemical Property of (S)-4--3-<<(1,1-dimethylethyl)diphenylsilyl>oxy>butanoic acid methyl ester

Chemical Property:

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Technology Process of (S)-4--3-<<(1,1-dimethylethyl)diphenylsilyl>oxy>butanoic acid methyl ester

There total 3 articles about (S)-4--3-<<(1,1-dimethylethyl)diphenylsilyl>oxy>butanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

triisopropyl phosphite (116-17-6) + (S)-4-iodo-3-<<(1,1-dimethylethyl)diphenylsilyl>oxy>butanoic acid methyl ester (119673-72-2) → (S)-4--3-<<(1,1-dimethylethyl)diphenylsilyl>oxy>butanoic acid methyl ester (119900-72-0)

Guidance literature:

at 150 - 160 ℃; for 16h;

DOI:10.1021/jm00173a007

Reference yield:

Methyl 3S-((t-butyl)diphenylsilyloxy)-4-bromo butanoate (119673-71-1) → (S)-4--3-<<(1,1-dimethylethyl)diphenylsilyl>oxy>butanoic acid methyl ester (119900-72-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium iodide / butan-2-one / 5 h / Heating

2: 75 percent / 16.5 h / 155 °C

With sodium iodide; In butanone;

DOI:10.1021/jm00113a019

Reference yield:

(S)-bromo-3-hydroxybutyric acid methyl ester (88759-56-2) → (S)-4--3-<<(1,1-dimethylethyl)diphenylsilyl>oxy>butanoic acid methyl ester (119900-72-0)

Guidance literature:

Multi-step reaction with 3 steps

1: imidazole, DMAP / dimethylformamide / Ambient temperature

2: sodium iodide / butan-2-one / 5 h / Heating

3: 75 percent / 16.5 h / 155 °C

With 1H-imidazole; dmap; sodium iodide; In N,N-dimethyl-formamide; butanone;

DOI:10.1021/jm00113a019

upstream raw materials:

triisopropyl phosphite

(S)-4-iodo-3-<<(1,1-dimethylethyl)diphenylsilyl>oxy>butanoic acid methyl ester

(S)-bromo-3-hydroxybutyric acid methyl ester

Methyl 3S-((t-butyl)diphenylsilyloxy)-4-bromo butanoate

Downstream raw materials:

Methyl (S)-4-phosphono-3-(tert-butyldiphenylsiloxy)butyrate

C₂₇H₄₅O₆PSi₃

(S)-3-(tert-Butyl-diphenyl-silanyloxy)-4-{[(E)-2-(4'-fluoro-3,5,3'-trimethyl-biphenyl-2-yl)-vinyl]-methoxy-phosphinoyl}-butyric acid methyl ester

(S,Z)-4-[[2-[4'-Fluoro-3,3',5-trimethyl[1,1'-biphenyl]-2-yl]ethenyl]-methoxyphosphinyl]-3-t-butyldiphenyl-silyloxy-butanoic acid, methyl ester

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