ethyl 2-benzyl-6-hydroxyhexanoate

Base Information

Chemical Name:ethyl 2-benzyl-6-hydroxyhexanoate
CAS No.:203259-85-2
Molecular Formula:C₁₅H₂₂O₃
Molecular Weight:250.338
Hs Code.:

Synonyms:ethyl 2-benzyl-6-hydroxyhexanoate

Suppliers and Price of ethyl 2-benzyl-6-hydroxyhexanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of ethyl 2-benzyl-6-hydroxyhexanoate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

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Technology Process of ethyl 2-benzyl-6-hydroxyhexanoate

There total 6 articles about ethyl 2-benzyl-6-hydroxyhexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-benzyl-6-(tert-butyl-dimethyl-silanyloxy)-hexanoic acid ethyl ester

: 203259-85-2
ethyl 2-benzyl-6-hydroxyhexanoate

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 23 ℃; for 4h;
DOI:10.1021/jm990447m

Reference yield:

: 1191-25-9
6-Hydroxyhexanoic acid

: 203259-85-2
ethyl 2-benzyl-6-hydroxyhexanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: K₂CO₃ / dimethylformamide / 4 h / 80 °C

2.1: imidazole / dimethylformamide / 16 h / 23 °C

3.1: lithium diisopropylamide / hexane; tetrahydrofuran / 0.75 h / -78 °C

3.2: DMPU / hexane; tetrahydrofuran / 1 h / -15 °C

4.1: tetrabutylammonium fluoride / tetrahydrofuran / 4 h / 23 °C

With 1H-imidazole; tetrabutyl ammonium fluoride; potassium carbonate; lithium diisopropyl amide; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; 1.1: Esterification / 2.1: silylation / 3.1: Metallation / 3.2: Alkylation / 4.1: desilylation;
DOI:10.1021/jm990447m

Reference yield:

: 5299-60-5
6-hydroxy-hexanoic acid ethyl ester

: 203259-85-2
ethyl 2-benzyl-6-hydroxyhexanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: imidazole / dimethylformamide / 16 h / 23 °C

2.1: lithium diisopropylamide / hexane; tetrahydrofuran / 0.75 h / -78 °C

2.2: DMPU / hexane; tetrahydrofuran / 1 h / -15 °C

3.1: tetrabutylammonium fluoride / tetrahydrofuran / 4 h / 23 °C

With 1H-imidazole; tetrabutyl ammonium fluoride; lithium diisopropyl amide; In tetrahydrofuran; hexane; N,N-dimethyl-formamide; 1.1: silylation / 2.1: Metallation / 2.2: Alkylation / 3.1: desilylation;
DOI:10.1021/jm990447m