cis-1,3,4,5-tetrahydro-3-hydroxy-7-methoxy-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one

Base Information

Chemical Name:cis-1,3,4,5-tetrahydro-3-hydroxy-7-methoxy-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one
CAS No.:128510-73-6
Molecular Formula:C₁₈H₁₉NO₄
Molecular Weight:313.353
Hs Code.:

Synonyms:cis-1,3,4,5-tetrahydro-3-hydroxy-7-methoxy-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one

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Chemical Property of cis-1,3,4,5-tetrahydro-3-hydroxy-7-methoxy-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one

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Technology Process of cis-1,3,4,5-tetrahydro-3-hydroxy-7-methoxy-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one

There total 1 articles about cis-1,3,4,5-tetrahydro-3-hydroxy-7-methoxy-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 128510-73-6
cis-1,3,4,5-tetrahydro-3-hydroxy-7-methoxy-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one

Guidance literature:

Reference yield: 96.0%

: 128510-73-6
cis-1,3,4,5-tetrahydro-3-hydroxy-7-methoxy-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one

: (S)--2-pyrrolidinyl>methyl p-toluenesulfonate

: (3R,4S)-1-[(S)-1-(2,2-Dimethyl-propionyl)-pyrrolidin-2-ylmethyl]-3-hydroxy-7-methoxy-4-(4-methoxy-phenyl)-1,3,4,5-tetrahydro-benzo[b]azepin-2-one

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 50 ℃;
DOI:10.1021/jm00092a011

Reference yield:

: 128510-73-6
cis-1,3,4,5-tetrahydro-3-hydroxy-7-methoxy-4-(4-methoxyphenyl)-2H-1-benzazepin-2-one

: Acetic acid (3R,4S)-1-[(S)-1-(2,2-dimethyl-propionyl)-pyrrolidin-2-ylmethyl]-7-methoxy-4-(4-methoxy-phenyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / cesium carbonate / dimethylformamide / 50 °C

2: 82 percent / 2.) 4-(dimethylamino)pyridine / CH₂Cl₂ / 24 h / Ambient temperature

With dmap; caesium carbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00092a011