1-(3,4,5-trimethoxy)phenyl-3-hydroxymethyl-9-(3-phenylpropyl)-β-carboline

Base Information

Chemical Name:1-(3,4,5-trimethoxy)phenyl-3-hydroxymethyl-9-(3-phenylpropyl)-β-carboline
CAS No.:1145668-40-1
Molecular Formula:C₃₀H₃₀N₂O₄
Molecular Weight:482.579
Hs Code.:

Synonyms:1-(3,4,5-trimethoxy)phenyl-3-hydroxymethyl-9-(3-phenylpropyl)-β-carboline

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Chemical Property of 1-(3,4,5-trimethoxy)phenyl-3-hydroxymethyl-9-(3-phenylpropyl)-β-carboline

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Technology Process of 1-(3,4,5-trimethoxy)phenyl-3-hydroxymethyl-9-(3-phenylpropyl)-β-carboline

There total 5 articles about 1-(3,4,5-trimethoxy)phenyl-3-hydroxymethyl-9-(3-phenylpropyl)-β-carboline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1015792-23-0
ethyl 1-(3,4,5-trimethoxy)phenyl-9-(3-phenylpropyl)-β-carboline-3-carboxylate

: 1145668-40-1
1-(3,4,5-trimethoxy)phenyl-3-hydroxymethyl-9-(3-phenylpropyl)-β-carboline

Guidance literature:: ethyl 1-(3,4,5-trimethoxy)phenyl-9-(3-phenylpropyl)-β-carboline-3-carboxylate; With lithium borohydride; In tetrahydrofuran; at 20 ℃; for 9h;

With hydrogenchloride; water; In tetrahydrofuran; for 4h;

With sodium hydroxide; water; In tetrahydrofuran;
DOI:10.1016/j.ejmech.2008.03.030

Reference yield:

: 73-22-3,27732-43-0,80206-30-0,27813-82-7
L-Tryptophan

: 1145668-40-1
1-(3,4,5-trimethoxy)phenyl-3-hydroxymethyl-9-(3-phenylpropyl)-β-carboline

Guidance literature:: Multi-step reaction with 5 steps

1: acetic acid / 3 h / Reflux

2: thionyl chloride / 4 h / Reflux

3: sulfur / 5,5-dimethyl-1,3-cyclohexadiene / 8 h / Reflux

4: sodium hydride / N,N-dimethyl-formamide / 0.5 - 2 h / 20 °C

5: lithium borohydride / tetrahydrofuran / 20 °C

With lithium borohydride; thionyl chloride; sodium hydride; sulfur; acetic acid; In tetrahydrofuran; 5,5-dimethyl-1,3-cyclohexadiene; N,N-dimethyl-formamide;
DOI:10.1039/c5md00312a

Reference yield:

: 86-81-7
3,4,5-trimethoxy-benzaldehyde

: 1145668-40-1
1-(3,4,5-trimethoxy)phenyl-3-hydroxymethyl-9-(3-phenylpropyl)-β-carboline

Guidance literature:: Multi-step reaction with 5 steps

1: acetic acid / 3 h / Reflux

2: thionyl chloride / 4 h / Reflux

3: sulfur / 5,5-dimethyl-1,3-cyclohexadiene / 8 h / Reflux

4: sodium hydride / N,N-dimethyl-formamide / 0.5 - 2 h / 20 °C

5: lithium borohydride / tetrahydrofuran / 20 °C

With lithium borohydride; thionyl chloride; sodium hydride; sulfur; acetic acid; In tetrahydrofuran; 5,5-dimethyl-1,3-cyclohexadiene; N,N-dimethyl-formamide;
DOI:10.1039/c5md00312a