ethyl 2-[3'-(1-adamantyl)-4'-benzyloxy-2-chloro-1,1'-biphenyl-4-ylthio]acetate

Base Information

Chemical Name:ethyl 2-[3'-(1-adamantyl)-4'-benzyloxy-2-chloro-1,1'-biphenyl-4-ylthio]acetate
CAS No.:1308279-98-2
Molecular Formula:C₃₃H₃₅ClO₃S
Molecular Weight:547.158
Hs Code.:

Synonyms:ethyl 2-[3'-(1-adamantyl)-4'-benzyloxy-2-chloro-1,1'-biphenyl-4-ylthio]acetate

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Chemical Property of ethyl 2-[3'-(1-adamantyl)-4'-benzyloxy-2-chloro-1,1'-biphenyl-4-ylthio]acetate

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Technology Process of ethyl 2-[3'-(1-adamantyl)-4'-benzyloxy-2-chloro-1,1'-biphenyl-4-ylthio]acetate

There total 5 articles about ethyl 2-[3'-(1-adamantyl)-4'-benzyloxy-2-chloro-1,1'-biphenyl-4-ylthio]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1308279-94-8
ethyl 2-(4-bromo-3-chlorophenylthio)acetate

: 221137-01-5
3-(1-adamantyl)-4-benzyloxyphenylboronic acid

: 1308279-98-2
ethyl 2-[3'-(1-adamantyl)-4'-benzyloxy-2-chloro-1,1'-biphenyl-4-ylthio]acetate

Guidance literature:: With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; for 6h; Inert atmosphere; Reflux;
DOI:10.1021/jm200051z

Reference yield:

: 21402-26-6
4-bromo-3-chloroaniline

: 1308279-98-2
ethyl 2-[3'-(1-adamantyl)-4'-benzyloxy-2-chloro-1,1'-biphenyl-4-ylthio]acetate

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogenchloride; sodium nitrite / water / -5 - 0 °C

2: water / 75 °C

3: potassium hydroxide / ethanol / 17 h / Reflux; Inert atmosphere

4: potassium carbonate / acetone / 18 h / Reflux; Inert atmosphere

5: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 6 h / Inert atmosphere; Reflux

With hydrogenchloride; potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; potassium hydroxide; sodium nitrite; In ethanol; water; N,N-dimethyl-formamide; acetone; 5: Suzuki coupling;
DOI:10.1021/jm200051z

Reference yield:

: C₆H₃BrClN₂⁽¹⁺⁾*Cl^(1-)

: 1308279-98-2
ethyl 2-[3'-(1-adamantyl)-4'-benzyloxy-2-chloro-1,1'-biphenyl-4-ylthio]acetate

Guidance literature:: Multi-step reaction with 4 steps

1: water / 75 °C

2: potassium hydroxide / ethanol / 17 h / Reflux; Inert atmosphere

3: potassium carbonate / acetone / 18 h / Reflux; Inert atmosphere

4: potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 6 h / Inert atmosphere; Reflux

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; potassium hydroxide; In ethanol; water; N,N-dimethyl-formamide; acetone; 4: Suzuki coupling;
DOI:10.1021/jm200051z