6(R)-<2-<8(S)-<(2,2-dimethylbutyryl)oxy>-2(S),6(R)-dimethyl-5(R)-(phenethyloxy)-1,2,3,4,4a(R),5,6,7,8,8a(R)-decahydronaphthyl-1(S)>ethyl>-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one

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Chemical Name:6(R)-<2-<8(S)-<(2,2-dimethylbutyryl)oxy>-2(S),6(R)-dimethyl-5(R)-(phenethyloxy)-1,2,3,4,4a(R),5,6,7,8,8a(R)-decahydronaphthyl-1(S)>ethyl>-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one
CAS No.:127343-09-3
Molecular Formula:C₃₃H₅₀O₆
Molecular Weight:542.756
Hs Code.:

6(R)-<2-<8(S)-<(2,2-dimethylbutyryl)oxy>-2(S),6(R)-dimethyl-5(R)-(phenethyloxy)-1,2,3,4,4a(R),5,6,7,8,8a(R)-decahydronaphthyl-1(S)>ethyl>-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one

Synonyms:6(R)-<2-<8(S)-<(2,2-dimethylbutyryl)oxy>-2(S),6(R)-dimethyl-5(R)-(phenethyloxy)-1,2,3,4,4a(R),5,6,7,8,8a(R)-decahydronaphthyl-1(S)>ethyl>-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one

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Chemical Property of 6(R)-<2-<8(S)-<(2,2-dimethylbutyryl)oxy>-2(S),6(R)-dimethyl-5(R)-(phenethyloxy)-1,2,3,4,4a(R),5,6,7,8,8a(R)-decahydronaphthyl-1(S)>ethyl>-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one

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Technology Process of 6(R)-<2-<8(S)-<(2,2-dimethylbutyryl)oxy>-2(S),6(R)-dimethyl-5(R)-(phenethyloxy)-1,2,3,4,4a(R),5,6,7,8,8a(R)-decahydronaphthyl-1(S)>ethyl>-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one

There total 10 articles about 6(R)-<2-<8(S)-<(2,2-dimethylbutyryl)oxy>-2(S),6(R)-dimethyl-5(R)-(phenethyloxy)-1,2,3,4,4a(R),5,6,7,8,8a(R)-decahydronaphthyl-1(S)>ethyl>-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 127343-21-9
6(R)-<2-<8(S)-<(2,2-dimethylbutyryl)oxy>-2(S),6(R)-dimethyl-5(R)-(phenethyloxy)-1,2,3,4,4a(R),5,6,7,8,8a(R)-decahydronaphthyl-1(S)>ethyl>-4(R)-<(tert-butyldiphenylsilyl)oxy>-3,4,5,6-tetrahydro-2H-pyran-2-one

: 127343-09-3
6(R)-<2-<8(S)-<(2,2-dimethylbutyryl)oxy>-2(S),6(R)-dimethyl-5(R)-(phenethyloxy)-1,2,3,4,4a(R),5,6,7,8,8a(R)-decahydronaphthyl-1(S)>ethyl>-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one

Guidance literature:: With tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; at 45 ℃; for 2h;
DOI:10.1021/jm00112a027

Reference yield:

: 4747-15-3
1-(2-methoxyvinyl)benzene

: 127343-09-3
6(R)-<2-<8(S)-<(2,2-dimethylbutyryl)oxy>-2(S),6(R)-dimethyl-5(R)-(phenethyloxy)-1,2,3,4,4a(R),5,6,7,8,8a(R)-decahydronaphthyl-1(S)>ethyl>-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: (+/-)-camphorsulfonic acid / CH₂Cl₂ / 3 h

2: H₂ / 10percent Pd/C / ethyl acetate / 8 h / 25 °C / 760 Torr

3: 100 percent / tetra-butylammonium fluoride, AcOH / tetrahydrofuran / 2 h / 45 °C

With camphor-10-sulfonic acid; tetrabutyl ammonium fluoride; hydrogen; acetic acid; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1021/jm00112a027

Reference yield:

: 123049-81-0,79902-63-9
simvastatin

: 127343-09-3
6(R)-<2-<8(S)-<(2,2-dimethylbutyryl)oxy>-2(S),6(R)-dimethyl-5(R)-(phenethyloxy)-1,2,3,4,4a(R),5,6,7,8,8a(R)-decahydronaphthyl-1(S)>ethyl>-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one

Guidance literature:: Multi-step reaction with 9 steps

1: 1.) H₂, 2.) thiourea / 1.) (Ph₃P)3RhCl / 1.) toluene, ethanol, 60 psi, RT, 40 h, 2.) toluene, 60 deg C, 1.5

2: imidazole / dimethylformamide / 4 h / 25 °C

3: N-bromosuccinimide, H₂O / tetrahydrofuran; dimethylsulfoxide / 1 h / 5 °C

4: pyridinium chlorochromate (PCC), 4 A sieves / CH₂Cl₂ / 1 h / 0 - 20 °C

5: Zn, acetic acid / tetrahydrofuran / 1 h / Ambient temperature

6: NaBH₄ / tetrahydrofuran; H₂O / 0.58 h / 0 °C

7: (+/-)-camphorsulfonic acid / CH₂Cl₂ / 3 h

8: H₂ / 10percent Pd/C / ethyl acetate / 8 h / 25 °C / 760 Torr

9: 100 percent / tetra-butylammonium fluoride, AcOH / tetrahydrofuran / 2 h / 45 °C

With 1H-imidazole; sodium tetrahydroborate; N-Bromosuccinimide; 4 A molecular sieve; camphor-10-sulfonic acid; tetrabutyl ammonium fluoride; water; hydrogen; acetic acid; thiourea; pyridinium chlorochromate; zinc; palladium on activated charcoal; Wilkinson's catalyst; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00112a027