methyl (4S,1'S)-2-[1-(tert-butoxycarbonylamino)-2-phenylethyl]-4,5-dihydrooxazole-4-carboxylate

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Chemical Name:methyl (4S,1'S)-2-[1-(tert-butoxycarbonylamino)-2-phenylethyl]-4,5-dihydrooxazole-4-carboxylate
CAS No.:142342-86-7
Molecular Formula:C₁₈H₂₄N₂O₅
Molecular Weight:348.399
Hs Code.:

Synonyms:methyl (4S,1'S)-2-[1-(tert-butoxycarbonylamino)-2-phenylethyl]-4,5-dihydrooxazole-4-carboxylate

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Chemical Property of methyl (4S,1'S)-2-[1-(tert-butoxycarbonylamino)-2-phenylethyl]-4,5-dihydrooxazole-4-carboxylate

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Technology Process of methyl (4S,1'S)-2-[1-(tert-butoxycarbonylamino)-2-phenylethyl]-4,5-dihydrooxazole-4-carboxylate

There total 4 articles about methyl (4S,1'S)-2-[1-(tert-butoxycarbonylamino)-2-phenylethyl]-4,5-dihydrooxazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 34290-59-0
(S)-methyl 2-((2S)-2-[(tert-butoxycarbonyl)-3-phenylpropanamido]-3-hydroxy)-propanoate

: 142342-86-7
methyl (4S,1'S)-2-[1-(tert-butoxycarbonylamino)-2-phenylethyl]-4,5-dihydrooxazole-4-carboxylate

Guidance literature:: (S)-methyl 2-((2S)-2-[(tert-butoxycarbonyl)-3-phenylpropanamido]-3-hydroxy)-propanoate; With diethylamino-sulfur trifluoride; In dichloromethane; at -78 ℃; for 1h;

With potassium carbonate; In dichloromethane; at -78 - 20 ℃;
DOI:10.1021/jacs.0c05541

Reference yield: 78.0%

: 940950-88-9
methyl (2S,2'S)-2-azido-3-(N-Boc-phenylalanyloxy)propionate

: 142342-86-7
methyl (4S,1'S)-2-[1-(tert-butoxycarbonylamino)-2-phenylethyl]-4,5-dihydrooxazole-4-carboxylate

Guidance literature:: With triphenylphosphine; In tetrahydrofuran; at -20 - 40 ℃; for 6.25h; chemoselective reaction; Inert atmosphere;
DOI:10.1002/ejoc.201300160

Reference yield: 61.0%

: 34290-59-0
(S)-methyl 2-((2S)-2-[(tert-butoxycarbonyl)-3-phenylpropanamido]-3-hydroxy)-propanoate

: 142342-86-7,142342-87-8
(R)-2-((S)-1-tert-Butoxycarbonylamino-2-phenyl-ethyl)-4,5-dihydro-oxazole-4-carboxylic acid methyl ester

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; Ambient temperature;
DOI:10.1016/S0040-4039(00)78864-2