N-<<(2R,3R)-3-(ethoxycarbonyl)aziridin-2-yl>carbonyl>-(S)-leucine benzyl ester

Base Information

Chemical Name:N-<<(2R,3R)-3-(ethoxycarbonyl)aziridin-2-yl>carbonyl>-(S)-leucine benzyl ester
CAS No.:221345-60-4
Molecular Formula:C₁₉H₂₆N₂O₅
Molecular Weight:362.426
Hs Code.:

Synonyms:N-<<(2R,3R)-3-(ethoxycarbonyl)aziridin-2-yl>carbonyl>-(S)-leucine benzyl ester

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Chemical Property of N-<<(2R,3R)-3-(ethoxycarbonyl)aziridin-2-yl>carbonyl>-(S)-leucine benzyl ester

Chemical Property:

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Technology Process of N-<<(2R,3R)-3-(ethoxycarbonyl)aziridin-2-yl>carbonyl>-(S)-leucine benzyl ester

There total 1 articles about N-<<(2R,3R)-3-(ethoxycarbonyl)aziridin-2-yl>carbonyl>-(S)-leucine benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 1738-77-8
L-leucine benzyl ester p-toluenesulfonate

: 167933-78-0
(2R,3R)-aziridine-2,3-dicarboxylic acid monoethyl ester

: 221345-60-4
N-<<(2R,3R)-3-(ethoxycarbonyl)aziridin-2-yl>carbonyl>-(S)-leucine benzyl ester

Guidance literature:: With diphenyl phosphoryl azide; triethylamine; In N,N-dimethyl-formamide; for 10h;
DOI:10.1021/jm981061z

Reference yield:

: 221345-60-4
N-<<(2R,3R)-3-(ethoxycarbonyl)aziridin-2-yl>carbonyl>-(S)-leucine benzyl ester

: 221345-63-7
N-<<(2R,3R)-3-(ethoxycarbonyl)aziridin-2-yl>carbonyl>-(S)-leucyl-(S)-proline benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / H₂ / 10 percent Pd/C / methanol / 1.5 h / 760 Torr / Ambient temperature

2: 57 percent / diphenyl phosphorazidate, Et₃N / dimethylformamide / 10 h

With diphenyl phosphoryl azide; hydrogen; triethylamine; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm981061z

Reference yield:

: 221345-60-4
N-<<(2R,3R)-3-(ethoxycarbonyl)aziridin-2-yl>carbonyl>-(S)-leucine benzyl ester

: 221345-68-2
N-<(2R,3R)-1-<-3-(ethoxycarbonyl)aziridin-2-yl>carbonyl>-(S)-leucyl-(S)-proline benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / H₂ / 10 percent Pd/C / methanol / 1.5 h / 760 Torr / Ambient temperature

2: 57 percent / diphenyl phosphorazidate, Et₃N / dimethylformamide / 10 h

3: 1.) dicyclohexylcarbodiimide, 2.) 4-(dimethylamino)pyridine / 1.) CH₂Cl₂, 0 deg C, 45 min, 2.) CH₂Cl₂, a) 0 deg C, 1 h, b) RT, 4 h

With dmap; diphenyl phosphoryl azide; hydrogen; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm981061z