3',5'-O-(di-tert-butylsilanediyl)-4-N-benzoyl-2'-C-β-methyl-2'-O-(tert-butyldimethylsilyl)cytidine

Base Information

Chemical Name:3',5'-O-(di-tert-butylsilanediyl)-4-N-benzoyl-2'-C-β-methyl-2'-O-(tert-butyldimethylsilyl)cytidine
CAS No.:220503-66-2
Molecular Formula:C₃₁H₄₉N₃O₆Si₂
Molecular Weight:615.918
Hs Code.:

Synonyms:3',5'-O-(di-tert-butylsilanediyl)-4-N-benzoyl-2'-C-β-methyl-2'-O-(tert-butyldimethylsilyl)cytidine

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Chemical Property of 3',5'-O-(di-tert-butylsilanediyl)-4-N-benzoyl-2'-C-β-methyl-2'-O-(tert-butyldimethylsilyl)cytidine

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Technology Process of 3',5'-O-(di-tert-butylsilanediyl)-4-N-benzoyl-2'-C-β-methyl-2'-O-(tert-butyldimethylsilyl)cytidine

There total 5 articles about 3',5'-O-(di-tert-butylsilanediyl)-4-N-benzoyl-2'-C-β-methyl-2'-O-(tert-butyldimethylsilyl)cytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 69739-34-0
t-butyldimethylsiyl triflate

: 220503-65-1
3',5'-O-(di-tert-butylsilanediyl)-2'-C-β-methyl-4-N-benzoylcytidine

: 220503-66-2
3',5'-O-(di-tert-butylsilanediyl)-4-N-benzoyl-2'-C-β-methyl-2'-O-(tert-butyldimethylsilyl)cytidine

Guidance literature:: With tert-butylmagnesium chloride; 0 deg C to rt;
DOI:10.1021/jo981329u

Reference yield:

: 26661-13-2
4-N-benzoylcytosine

: 220503-66-2
3',5'-O-(di-tert-butylsilanediyl)-4-N-benzoyl-2'-C-β-methyl-2'-O-(tert-butyldimethylsilyl)cytidine

Guidance literature:: Multi-step reaction with 5 steps

1: (NH₄)2SO₄ / Heating

2: 86 percent / SnCl₄ / acetonitrile

3: 94 percent / aq. NaOH / pyridine; methanol / 0.5 h / -20 - -15 °C

4: 95 percent / AgNO₃ / dimethylformamide / 0 deg C to rt

5: 64 percent / t-BuMgCl / 0 deg C to rt

With ammonium sulfate; sodium hydroxide; tert-butylmagnesium chloride; tin(IV) chloride; silver nitrate; In pyridine; methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo981329u

Reference yield:

: 64339-87-3
N₄,O-bis(trimethylsilyl)-N₄-benzoylcytosine

: 220503-66-2
3',5'-O-(di-tert-butylsilanediyl)-4-N-benzoyl-2'-C-β-methyl-2'-O-(tert-butyldimethylsilyl)cytidine

Guidance literature:: Multi-step reaction with 4 steps

1: 86 percent / SnCl₄ / acetonitrile

2: 94 percent / aq. NaOH / pyridine; methanol / 0.5 h / -20 - -15 °C

3: 95 percent / AgNO₃ / dimethylformamide / 0 deg C to rt

4: 64 percent / t-BuMgCl / 0 deg C to rt

With sodium hydroxide; tert-butylmagnesium chloride; tin(IV) chloride; silver nitrate; In pyridine; methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo981329u