N-[5-Fluoro-2-(4-fluorobenzyloxy)-pyrimidin-4-yl]-S-(2-nitrophenyl)-thiohydroxylamine

Base Information

Chemical Name:N-[5-Fluoro-2-(4-fluorobenzyloxy)-pyrimidin-4-yl]-S-(2-nitrophenyl)-thiohydroxylamine
CAS No.:1174376-49-8
Molecular Formula:C₁₇H₁₂F₂N₄O₃S
Molecular Weight:390.37
Hs Code.:

Synonyms:N-[5-Fluoro-2-(4-fluorobenzyloxy)-pyrimidin-4-yl]-S-(2-nitrophenyl)-thiohydroxylamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[5-Fluoro-2-(4-fluorobenzyloxy)-pyrimidin-4-yl]-S-(2-nitrophenyl)-thiohydroxylamine

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Technology Process of N-[5-Fluoro-2-(4-fluorobenzyloxy)-pyrimidin-4-yl]-S-(2-nitrophenyl)-thiohydroxylamine

There total 2 articles about N-[5-Fluoro-2-(4-fluorobenzyloxy)-pyrimidin-4-yl]-S-(2-nitrophenyl)-thiohydroxylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 1174376-11-4
5-fluoro-2-(4-fluorophenylmethoxy)pyrimidin-4 amine

: 7669-54-7
2-nitrobenzenesulfenyl chloride

: 1174376-49-8
N-[5-Fluoro-2-(4-fluorobenzyloxy)-pyrimidin-4-yl]-S-(2-nitrophenyl)-thiohydroxylamine

Guidance literature:: With potassium tert-butylate; In tert-butyl alcohol; for 1h;

Reference yield:

: 459-56-3
4-fluorobenzylic alcohol

: 1174376-49-8
N-[5-Fluoro-2-(4-fluorobenzyloxy)-pyrimidin-4-yl]-S-(2-nitrophenyl)-thiohydroxylamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / 1,4-dioxane / 0.17 h

1.2: 20 - 120 °C / Microwave irradiation

2.1: potassium tert-butylate / tert-butyl alcohol / 1 h

With potassium tert-butylate; sodium hydride; In 1,4-dioxane; tert-butyl alcohol;