4-Fluoro-3-nitrophenylboronic acid

Base Information

• Chemical Name: 4-Fluoro-3-nitrophenylboronic acid
• CAS No.: 352530-22-4
• Molecular Formula: C6H5BFNO4
• Molecular Weight: 184.919
• Hs Code.: 2931900090
• Mol file: 352530-22-4.mol

Synonyms:Boronicacid, (4-fluoro-3-nitrophenyl)- (9CI);4-Fluoro-3-nitrophenylboronic acid;

Chemical Property of 4-Fluoro-3-nitrophenylboronic acid

Chemical Property:

• Vapor Pressure: 4.95E-06mmHg at 25°C
• Refractive Index: 1.548
• Boiling Point: 367 °C at 760 mmHg
• PKA: 7.02±0.10(Predicted)
• Flash Point: 175.7 °C
• PSA: 86.28000
• Density: 1.49 g/cm³
• LogP: -0.06310
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

4-Fluoro-3-nitrophenylboronicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: suzuki reaction

Technology Process of 4-Fluoro-3-nitrophenylboronic acid

There total 2 articles about 4-Fluoro-3-nitrophenylboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.5%

4-fluoroboronic acid (1765-93-1) → (4-fluoro-3-nitro-phenyl)boronic acid (352530-22-4)

Guidance literature:

With nitric acid; In ethanol; at -45 - -35 ℃;

Reference yield:

1-Bromo-4-fluorobenzene (460-00-4) → (4-fluoro-3-nitro-phenyl)boronic acid (352530-22-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: magnesium hydroxide / tetrahydrofuran / 2 h / 50 °C / Inert atmosphere

1.2: 3 h / -5 °C / Inert atmosphere

1.3: 0.5 h / 0 °C / Inert atmosphere

2.1: nitric acid / ethanol / -45 - -35 °C

With magnesium hydroxide; nitric acid; In tetrahydrofuran; ethanol;

Reference yield: 99.0%

piperidine (110-89-4) + (4-fluoro-3-nitro-phenyl)boronic acid (352530-22-4) → [3-nitro-4-(1-piperidyl)phenyl]boronic acid

Guidance literature:

With triethylamine; for 48h; Reflux;

upstream raw materials:

1-Bromo-4-fluorobenzene

4-fluoroboronic acid

Downstream raw materials:

tert-butyl 1-(4-fluoro-3-nitrophenyl)-3-isopropyl-1H-pyrazole-5-carboxylate

tert-butyl 4-{3-[(3R)-3-({1-[5-(4-fluoro-3-nitrophenyl)pyridin-3-yl]-3-methoxy-3-oxopropyl}carbamoyl)piperidin-1-yl]-3-oxopropyl}piperidine-1-carboxylate

tert-butyl 4-(4-(4-amino-3-(4-fluoro-3-nitrophenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)cyclohexyl)piperazine-1-carboxylate

1-(4-(4-(4-amino-3-(3-nitro-4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)cyclohexyl)piperazin-1-yl)ethanone

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