tert-butyl (2-(4-((6-chloro-3-nitropyridin-2-yl)amino)-phenyl)propan-2-yl)carbamate

Base Information

Chemical Name:tert-butyl (2-(4-((6-chloro-3-nitropyridin-2-yl)amino)-phenyl)propan-2-yl)carbamate
CAS No.:1313883-45-2
Molecular Formula:C₁₉H₂₃ClN₄O₄
Molecular Weight:406.869
Hs Code.:

Synonyms:tert-butyl (2-(4-((6-chloro-3-nitropyridin-2-yl)amino)-phenyl)propan-2-yl)carbamate

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Chemical Property of tert-butyl (2-(4-((6-chloro-3-nitropyridin-2-yl)amino)-phenyl)propan-2-yl)carbamate

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Technology Process of tert-butyl (2-(4-((6-chloro-3-nitropyridin-2-yl)amino)-phenyl)propan-2-yl)carbamate

There total 4 articles about tert-butyl (2-(4-((6-chloro-3-nitropyridin-2-yl)amino)-phenyl)propan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1313883-43-0
N-[4-(1-amino-1-methylethyl)phenyl]-6-chloro-3-nitropyridin-2-amine hydrochloride

: 1313883-45-2
tert-butyl (2-(4-((6-chloro-3-nitropyridin-2-yl)amino)-phenyl)propan-2-yl)carbamate

Guidance literature:: With sodium hydrogencarbonate; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: N-(4-(1-amino-1-methylethyl)phenyl)-6-chloro-3-nitropyridin-2-amine hydrochloride

: 1313883-45-2
tert-butyl (2-(4-((6-chloro-3-nitropyridin-2-yl)amino)-phenyl)propan-2-yl)carbamate

Guidance literature:: N-(4-(1-amino-1-methylethyl)phenyl)-6-chloro-3-nitropyridin-2-amine hydrochloride; With sodium hydrogencarbonate; In tetrahydrofuran; water; at 0 ℃;

di-tert-butyl dicarbonate; In tetrahydrofuran; water; at 0 - 20 ℃;
DOI:10.1021/acs.jmedchem.6b00619

Reference yield:

: 1313883-42-9
N-(2-(4-((6-chloro-3-nitropyridin-2-yl)amino)phenyl)propan-2-yl)-2-methylpropane-2-sulfinamide

: 1313883-45-2
tert-butyl (2-(4-((6-chloro-3-nitropyridin-2-yl)amino)-phenyl)propan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 0.5 h / 20 °C

2.1: sodium hydrogencarbonate / water; tetrahydrofuran / 0 °C

2.2: 0 - 20 °C

With hydrogenchloride; sodium hydrogencarbonate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;
DOI:10.1021/acs.jmedchem.6b00619