(S)-3-(3,4-dimethylphenyl)-2-phthalimido-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide

Base Information

Chemical Name:(S)-3-(3,4-dimethylphenyl)-2-phthalimido-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide
CAS No.:1582806-85-6
Molecular Formula:C₂₆H₁₇F₇N₂O₃
Molecular Weight:538.421
Hs Code.:

Synonyms:(S)-3-(3,4-dimethylphenyl)-2-phthalimido-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-3-(3,4-dimethylphenyl)-2-phthalimido-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide

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Technology Process of (S)-3-(3,4-dimethylphenyl)-2-phthalimido-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide

There total 6 articles about (S)-3-(3,4-dimethylphenyl)-2-phthalimido-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 31599-61-8
3,4-dimethyliodobenzene

: 1582806-46-9
(S)-2-phthalimido-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide

: 1582806-85-6
(S)-3-(3,4-dimethylphenyl)-2-phthalimido-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide

Guidance literature:: With α-picoline; palladium(II) trifluoroacetate; silver carbonate; trifluoroacetic acid; In 1,2-dichloro-ethane; at 100 ℃; for 20h;
DOI:10.1126/science.1249198

Reference yield:

: 31599-61-8
3,4-dimethyliodobenzene

: 1582806-46-9
(S)-2-phthalimido-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide

: 1582806-85-6
(S)-3-(3,4-dimethylphenyl)-2-phthalimido-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide

: C₃₄H₂₅F₇N₂O₃

Guidance literature:: With palladium(II) trifluoroacetate; silver carbonate; trifluoroacetic acid; In cyclohexane; at 100 ℃; for 20h; Overall yield = 81 %Spectr.; Sealed tube;
DOI:10.1002/adsc.201700707

Reference yield:

: 22509-74-6
N-ethoxycarbonylphthalimide

: 1582806-85-6
(S)-3-(3,4-dimethylphenyl)-2-phthalimido-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)propanamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium carbonate / water / 3 h / 20 °C

2: thionyl chloride; N,N-dimethyl-formamide / toluene / 3 h / 80 °C

3: toluene / 12 h / Reflux

4: palladium(II) trifluoroacetate; silver carbonate; trifluoroacetic acid; α-picoline / 1,2-dichloro-ethane / 20 h / 100 °C / Sealed tube

With α-picoline; thionyl chloride; palladium(II) trifluoroacetate; sodium carbonate; N,N-dimethyl-formamide; silver carbonate; trifluoroacetic acid; In water; 1,2-dichloro-ethane; toluene;