N₂-(3-fluoro-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl)-N₄-methyl-8-phenyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4-diamine

Base Information

• Chemical Name: N₂-(3-fluoro-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl)-N₄-methyl-8-phenyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4-diamine
• CAS No.: 1263870-30-9
• Molecular Formula: C₂₃H₂₃FN₈
• Molecular Weight: 430.488

Synonyms:N₂-(3-fluoro-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl)-N₄-methyl-8-phenyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4-diamine

Chemical Property of N₂-(3-fluoro-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl)-N₄-methyl-8-phenyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4-diamine

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Technology Process of N₂-(3-fluoro-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl)-N₄-methyl-8-phenyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4-diamine

There total 6 articles about N₂-(3-fluoro-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl)-N₄-methyl-8-phenyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N2-(3-fluoro-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl)-6-(4-methoxybenzyl)-N4-methyl-8-phenyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4-diamine (1263870-25-2) → N2-(3-fluoro-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl)-N4-methyl-8-phenyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4-diamine (1263870-30-9)

Guidance literature:

N₂-(3-fluoro-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl)-6-(4-methoxybenzyl)-N₄-methyl-8-phenyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4-diamine; With trifluorormethanesulfonic acid; In toluene; for 1h; Reflux;

With sodium hydrogencarbonate; In water;

Reference yield:

3,4-difluoronitrobenzene (369-34-6) → N2-(3-fluoro-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl)-N4-methyl-8-phenyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4-diamine (1263870-30-9)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium hydrogencarbonate / dimethyl sulfoxide / 48 h / 80 °C

2: hydrogen / palladium 10% on activated carbon / methanol / 78 h / 20 °C / Cooling with ice-water

3: sodium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane; water / 24 h / 110 °C / Inert atmosphere

4: trifluorormethanesulfonic acid / toluene / 1 h / Reflux

With trifluorormethanesulfonic acid; hydrogen; sodium hydrogencarbonate; sodium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; methanol; water; dimethyl sulfoxide; toluene;

Reference yield:

1-(2-Fluoro-4-nitro-phenyl)-3-methyl-1H-[1,2,4]triazole → N2-(3-fluoro-4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl)-N4-methyl-8-phenyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4-diamine (1263870-30-9)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 78 h / 20 °C / Cooling with ice-water

2: sodium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane; water / 24 h / 110 °C / Inert atmosphere

3: trifluorormethanesulfonic acid / toluene / 1 h / Reflux

With trifluorormethanesulfonic acid; hydrogen; sodium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; methanol; water; toluene;

upstream raw materials:

3,4-difluoronitrobenzene

ethyl 1-(4-methoxybenzyl)-4-oxo-5-phenylpiperidine-3-carboxylate

6-(4-methoxybenzyl)-8-phenyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione

2,4-dichloro-6-(4-methoxybenzyl)-8-phenyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

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