4-[(methyl-{1-[methyl-(1-methylcarbamoyl-2-phenyl-ethyl)-carbamoyl]-2-naphthalen-2-yl-ethyl}-carbamoyl)-methylene]-piperidine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:4-[(methyl-{1-[methyl-(1-methylcarbamoyl-2-phenyl-ethyl)-carbamoyl]-2-naphthalen-2-yl-ethyl}-carbamoyl)-methylene]-piperidine-1-carboxylic acid tert-butyl ester
CAS No.:193085-25-5
Molecular Formula:C₃₇H₄₆N₄O₅
Molecular Weight:626.796
Hs Code.:

4-[(methyl-{1-[methyl-(1-methylcarbamoyl-2-phenyl-ethyl)-carbamoyl]-2-naphthalen-2-yl-ethyl}-carbamoyl)-methylene]-piperidine-1-carboxylic acid <i>tert</i>-butyl ester

Synonyms:4-[(methyl-{1-[methyl-(1-methylcarbamoyl-2-phenyl-ethyl)-carbamoyl]-2-naphthalen-2-yl-ethyl}-carbamoyl)-methylene]-piperidine-1-carboxylic acid tert-butyl ester

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Chemical Property of 4-[(methyl-{1-[methyl-(1-methylcarbamoyl-2-phenyl-ethyl)-carbamoyl]-2-naphthalen-2-yl-ethyl}-carbamoyl)-methylene]-piperidine-1-carboxylic acid tert-butyl ester

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Technology Process of 4-[(methyl-{1-[methyl-(1-methylcarbamoyl-2-phenyl-ethyl)-carbamoyl]-2-naphthalen-2-yl-ethyl}-carbamoyl)-methylene]-piperidine-1-carboxylic acid tert-butyl ester

There total 5 articles about 4-[(methyl-{1-[methyl-(1-methylcarbamoyl-2-phenyl-ethyl)-carbamoyl]-2-naphthalen-2-yl-ethyl}-carbamoyl)-methylene]-piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 193085-25-5
4-[(methyl-{1-[methyl-(1-methylcarbamoyl-2-phenyl-ethyl)-carbamoyl]-2-naphthalen-2-yl-ethyl}-carbamoyl)-methylene]-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 10.9 g / aq. NaOH / tetrahydrofuran / 12 h / 20 °C

2.1: 9.5 g / toluene / 12 h / Heating

3.1: 5.49 g / aq. LiOH / dioxane / 12 h / 20 °C

4.1: 1-hydroxy-7-azabenzotriazole; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride / CH₂Cl₂; dimethylformamide

4.2: iPr₂NEt / CH₂Cl₂; dimethylformamide

With lithium hydroxide; sodium hydroxide; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; toluene; 1.1: Carboxylation / 2.1: Wittig reaction / 3.1: Hydrolysis / 4.1: Esterification / 4.2: Acylation;
DOI:10.1016/S0223-5234(99)80086-5

Reference yield:

: 41979-39-9
4-piperidone hydrochloride

: 193085-25-5
4-[(methyl-{1-[methyl-(1-methylcarbamoyl-2-phenyl-ethyl)-carbamoyl]-2-naphthalen-2-yl-ethyl}-carbamoyl)-methylene]-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 10.9 g / aq. NaOH / tetrahydrofuran / 12 h / 20 °C

2.1: 9.5 g / toluene / 12 h / Heating

3.1: 5.49 g / aq. LiOH / dioxane / 12 h / 20 °C

4.1: 1-hydroxy-7-azabenzotriazole; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride / CH₂Cl₂; dimethylformamide

4.2: iPr₂NEt / CH₂Cl₂; dimethylformamide

With lithium hydroxide; sodium hydroxide; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; toluene; 1.1: Carboxylation / 2.1: Wittig reaction / 3.1: Hydrolysis / 4.1: Esterification / 4.2: Acylation;
DOI:10.1016/S0223-5234(99)80086-5

Reference yield:

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 193085-25-5
4-[(methyl-{1-[methyl-(1-methylcarbamoyl-2-phenyl-ethyl)-carbamoyl]-2-naphthalen-2-yl-ethyl}-carbamoyl)-methylene]-piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 9.5 g / toluene / 12 h / Heating

2.1: 5.49 g / aq. LiOH / dioxane / 12 h / 20 °C

3.1: 1-hydroxy-7-azabenzotriazole; 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride / CH₂Cl₂; dimethylformamide

3.2: iPr₂NEt / CH₂Cl₂; dimethylformamide

With lithium hydroxide; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; toluene; 1.1: Wittig reaction / 2.1: Hydrolysis / 3.1: Esterification / 3.2: Acylation;
DOI:10.1016/S0223-5234(99)80086-5