(8R,9S,10R,13S,14S,17R)-17-ethynyl-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl tosylcarbamate

Base Information

Chemical Name:(8R,9S,10R,13S,14S,17R)-17-ethynyl-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl tosylcarbamate
CAS No.:166389-67-9
Molecular Formula:C₂₉H₃₅NO₅S
Molecular Weight:509.667
Hs Code.:

(8R,9S,10R,13S,14S,17R)-17-ethynyl-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl tosylcarbamate

Synonyms:(8R,9S,10R,13S,14S,17R)-17-ethynyl-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl tosylcarbamate

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Chemical Property of (8R,9S,10R,13S,14S,17R)-17-ethynyl-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl tosylcarbamate

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Technology Process of (8R,9S,10R,13S,14S,17R)-17-ethynyl-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl tosylcarbamate

There total 1 articles about (8R,9S,10R,13S,14S,17R)-17-ethynyl-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl tosylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 434-03-7
levonorgestrel

: 4083-64-1
Tosyl isocyanate

: 166389-67-9
(8R,9S,10R,13S,14S,17R)-17-ethynyl-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl tosylcarbamate

Guidance literature:: In tetrahydrofuran; at 20 - 60 ℃; for 2h;
DOI:10.1016/j.jfluchem.2018.04.002

Reference yield: 68.0%

: 166389-67-9
(8R,9S,10R,13S,14S,17R)-17-ethynyl-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl tosylcarbamate

: C₂₉H₃₅NO₅S

Guidance literature:: With triethylamine; copper(l) chloride; In tetrahydrofuran; for 4h; Heating;
DOI:10.1246/bcsj.67.2838

Reference yield: 30.0%

: 166389-67-9
(8R,9S,10R,13S,14S,17R)-17-ethynyl-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl tosylcarbamate

: C₂₉H₃₅NO₅S

: C₃₅H₃₈FNO₅S

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1-Fluoro-3-iodobenzene; potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 3h;
DOI:10.1055/s-1997-927