3-[6-((E)-2-Methoxycarbonyl-vinyl)-5-(4-phenyl-butoxy)-pyridin-2-ylmethylsulfanylmethyl]-benzoic acid methyl ester

Base Information

Chemical Name:3-[6-((E)-2-Methoxycarbonyl-vinyl)-5-(4-phenyl-butoxy)-pyridin-2-ylmethylsulfanylmethyl]-benzoic acid methyl ester
CAS No.:1025887-99-3
Molecular Formula:C₂₉H₃₁NO₅S
Molecular Weight:505.635
Hs Code.:

Synonyms:3-[6-((E)-2-Methoxycarbonyl-vinyl)-5-(4-phenyl-butoxy)-pyridin-2-ylmethylsulfanylmethyl]-benzoic acid methyl ester

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Chemical Property of 3-[6-((E)-2-Methoxycarbonyl-vinyl)-5-(4-phenyl-butoxy)-pyridin-2-ylmethylsulfanylmethyl]-benzoic acid methyl ester

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Technology Process of 3-[6-((E)-2-Methoxycarbonyl-vinyl)-5-(4-phenyl-butoxy)-pyridin-2-ylmethylsulfanylmethyl]-benzoic acid methyl ester

There total 12 articles about 3-[6-((E)-2-Methoxycarbonyl-vinyl)-5-(4-phenyl-butoxy)-pyridin-2-ylmethylsulfanylmethyl]-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 95902-29-7
methyl 3-(mercaptomethyl)benzoate

: (E)-3-[6-Chloromethyl-3-(4-phenyl-butoxy)-pyridin-2-yl]-acrylic acid methyl ester; hydrochloride

: 1025887-99-3
3-[6-((E)-2-Methoxycarbonyl-vinyl)-5-(4-phenyl-butoxy)-pyridin-2-ylmethylsulfanylmethyl]-benzoic acid methyl ester

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 1.5h;
DOI:10.1021/jm00046a017

Reference yield:

: 42097-42-7
3-hydroxy-2-hydroxymethyl-6-methylpyridine

: 1025887-99-3
3-[6-((E)-2-Methoxycarbonyl-vinyl)-5-(4-phenyl-butoxy)-pyridin-2-ylmethylsulfanylmethyl]-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: MnO₂ / CH₂Cl₂ / 6 h / Ambient temperature

2: K₂CO₃ / dimethylformamide / 1.5 h / 90 °C

3: toluene / 1 h / 50 °C

4: 50percent m-chloroperoxybenzoic acid / CH₂Cl₂ / 15 h / Ambient temperature

5: trifluoroacetic anhydride / dimethylformamide / 18 h / Ambient temperature

6: SOCl₂ / toluene / 4 h / Ambient temperature

7: Cs₂CO₃ / dimethylformamide / 1.5 h / 60 °C

With manganese(IV) oxide; thionyl chloride; potassium carbonate; caesium carbonate; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic anhydride; In dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00046a017

Reference yield:

: 66497-42-5
3-hydroxy-6-methylpicolinaldehyde

: 1025887-99-3
3-[6-((E)-2-Methoxycarbonyl-vinyl)-5-(4-phenyl-butoxy)-pyridin-2-ylmethylsulfanylmethyl]-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: K₂CO₃ / dimethylformamide / 1.5 h / 90 °C

2: toluene / 1 h / 50 °C

3: 50percent m-chloroperoxybenzoic acid / CH₂Cl₂ / 15 h / Ambient temperature

4: trifluoroacetic anhydride / dimethylformamide / 18 h / Ambient temperature

5: SOCl₂ / toluene / 4 h / Ambient temperature

6: Cs₂CO₃ / dimethylformamide / 1.5 h / 60 °C

With thionyl chloride; potassium carbonate; caesium carbonate; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic anhydride; In dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00046a017