(2R,3S)-2-(3-chloro-4-cyano-2-methylphenylamino)-3-hydroxybutanoic acid

Base Information

• Chemical Name: (2R,3S)-2-(3-chloro-4-cyano-2-methylphenylamino)-3-hydroxybutanoic acid
• CAS No.: 1182366-63-7
• Molecular Formula: C₁₂H₁₃ClN₂O₃
• Molecular Weight: 268.7
• Mol file: 1182366-63-7.mol

Synonyms:(2R,3S)-2-(3-chloro-4-cyano-2-methylphenylamino)-3-hydroxybutanoic acid

Chemical Property of (2R,3S)-2-(3-chloro-4-cyano-2-methylphenylamino)-3-hydroxybutanoic acid

Chemical Property:

• Boiling Point: 558.8±50.0 °C(Predicted)
• Density: 1.38±0.1 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,3S)-2-(3-chloro-4-cyano-2-methylphenylamino)-3-hydroxybutanoic acid

There total 1 articles about (2R,3S)-2-(3-chloro-4-cyano-2-methylphenylamino)-3-hydroxybutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

2-chloro-4-fluoro-3-methylbenzonitrile (796600-15-2) + D-Threonine (632-20-2,134357-96-3,7013-32-3,82822-12-6) → (2R,3S)-2-(3-chloro-4-cyano-2-methylphenylamino)-3-hydroxybutanoic acid (1182366-63-7)

Guidance literature:

2-chloro-4-fluoro-3-methylbenzonitrile; D-Threonine; With potassium carbonate; In dimethyl sulfoxide; at 75 ℃; for 24h;

With citric acid; In water; dimethyl sulfoxide; at 20 ℃;

Reference yield: 92.0%

(2R,3S)-2-(3-chloro-4-cyano-2-methylphenylamino)-3-hydroxybutanoic acid (1182366-63-7) + 4-(trifluoromethyl)benzoic acid hydrazide (339-59-3) → N'-((2R,3S)-2-(3-chloro-4-cyano-2-methylphenylamino)-3-hydroxybutanoyl)-4-(trifluoromethyl)benzohydrazide (1182368-96-2)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; at -45 - 20 ℃;

Reference yield: 91.0%

3-fluoro-benzoic acid hydrazide (499-55-8) + (2R,3S)-2-(3-chloro-4-cyano-2-methylphenylamino)-3-hydroxybutanoic acid (1182366-63-7) → N'-((2R,3S)-2-(3-chloro-4-cyano-2-methylphenylamino)-3-hydroxybutanoyl)-3-fluorobenzohydrazide (1182369-33-0)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; at -20 - 20 ℃; Inert atmosphere;

upstream raw materials:

2-chloro-4-fluoro-3-methylbenzonitrile

D-Threonine

Downstream raw materials:

(2R,3S)-N'-Acetyl-2-(3-chloro-4-cyano-2-methylphenylamino)-3-hydroxybutanehydrazide

N'-((2R,3S)-2-(3-chloro-4-cyano-2-methylphenylamino)-3-hydroxybutanoyl)-4-cyanobenzohydrazide

N'-((2R,3S)-2-(3-chloro-4-cyano-2-methylphenylamino)-3-hydroxybutanoyl)-4-fluoro-3-hydroxybenzohydrazide

N'-((2R,3S)-2-(3-chloro-4-cyano-2-methylphenylamino)-3-hydroxybutanoyl)-3-fluorobenzohydrazide