(3-[5-(2,5-difluoro-phenyl)-3-isobutyryl-2-phenyl-2,3-dihydro-[1,3,4]thiadiazol-2-yl]-propyl)-cyanamide

Base Information

Chemical Name:(3-[5-(2,5-difluoro-phenyl)-3-isobutyryl-2-phenyl-2,3-dihydro-[1,3,4]thiadiazol-2-yl]-propyl)-cyanamide
CAS No.:1018783-76-0
Molecular Formula:C₂₂H₂₂F₂N₄OS
Molecular Weight:428.506
Hs Code.:

Synonyms:(3-[5-(2,5-difluoro-phenyl)-3-isobutyryl-2-phenyl-2,3-dihydro-[1,3,4]thiadiazol-2-yl]-propyl)-cyanamide

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Chemical Property of (3-[5-(2,5-difluoro-phenyl)-3-isobutyryl-2-phenyl-2,3-dihydro-[1,3,4]thiadiazol-2-yl]-propyl)-cyanamide

Chemical Property:

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Technology Process of (3-[5-(2,5-difluoro-phenyl)-3-isobutyryl-2-phenyl-2,3-dihydro-[1,3,4]thiadiazol-2-yl]-propyl)-cyanamide

There total 9 articles about (3-[5-(2,5-difluoro-phenyl)-3-isobutyryl-2-phenyl-2,3-dihydro-[1,3,4]thiadiazol-2-yl]-propyl)-cyanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 885059-16-5
1-(2-(3-aminopropyl)-5-(2,5-difluorophenyl)-2-phenyl-1,3,4-thiadiazol-3(2H)-yl)-2-methylpropan-1-one

: 506-68-3
bromocyane

: 1018783-76-0
(3-[5-(2,5-difluoro-phenyl)-3-isobutyryl-2-phenyl-2,3-dihydro-[1,3,4]thiadiazol-2-yl]-propyl)-cyanamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 885060-36-6
2,5-difluoro-benzothiohydrazide

: 1018783-76-0
(3-[5-(2,5-difluoro-phenyl)-3-isobutyryl-2-phenyl-2,3-dihydro-[1,3,4]thiadiazol-2-yl]-propyl)-cyanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: ethanol; dichloromethane / 16 h / 20 °C

1.2: 16 h / 20 °C

2.1: triethylamine / dichloromethane / 20 °C

3.1: hydrogenchloride; hydrogen / palladium on activated charcoal / methanol / 0.75 h / 20 °C / 760.05 Torr

4.1: triethylamine / dichloromethane / 1 h / 20 °C

With hydrogenchloride; hydrogen; triethylamine; palladium on activated charcoal; In methanol; ethanol; dichloromethane;

Reference yield:

: 1018690-18-0
2-(2,5-difluoro-phenylcarbonothioylthio)acetic acid

: 1018783-76-0
(3-[5-(2,5-difluoro-phenyl)-3-isobutyryl-2-phenyl-2,3-dihydro-[1,3,4]thiadiazol-2-yl]-propyl)-cyanamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide; hydrazine / 14 h / 0 - 20 °C

2.1: ethanol; dichloromethane / 16 h / 20 °C

2.2: 16 h / 20 °C

3.1: triethylamine / dichloromethane / 20 °C

4.1: hydrogenchloride; hydrogen / palladium on activated charcoal / methanol / 0.75 h / 20 °C / 760.05 Torr

5.1: triethylamine / dichloromethane / 1 h / 20 °C

With hydrogenchloride; sodium hydroxide; hydrogen; triethylamine; hydrazine; palladium on activated charcoal; In methanol; ethanol; dichloromethane;