4-{3-[6-(3,4-dimethoxy-phenyl)-2-methyl-imidazo[1,2-b]pyridazin-3-yl]-pyrazole-1-sulfonyl}-benzonitrile

Base Information

Chemical Name:4-{3-[6-(3,4-dimethoxy-phenyl)-2-methyl-imidazo[1,2-b]pyridazin-3-yl]-pyrazole-1-sulfonyl}-benzonitrile
CAS No.:1083428-89-0
Molecular Formula:C₂₅H₂₀N₆O₄S
Molecular Weight:500.538
Hs Code.:

Synonyms:4-{3-[6-(3,4-dimethoxy-phenyl)-2-methyl-imidazo[1,2-b]pyridazin-3-yl]-pyrazole-1-sulfonyl}-benzonitrile

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Chemical Property of 4-{3-[6-(3,4-dimethoxy-phenyl)-2-methyl-imidazo[1,2-b]pyridazin-3-yl]-pyrazole-1-sulfonyl}-benzonitrile

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Technology Process of 4-{3-[6-(3,4-dimethoxy-phenyl)-2-methyl-imidazo[1,2-b]pyridazin-3-yl]-pyrazole-1-sulfonyl}-benzonitrile

There total 5 articles about 4-{3-[6-(3,4-dimethoxy-phenyl)-2-methyl-imidazo[1,2-b]pyridazin-3-yl]-pyrazole-1-sulfonyl}-benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1083428-88-9
6-(3,4-dimethoxy-phenyl)-2-methyl-3-(1H-pyrazol-3-yl)-imidazo[1,2-b]pyridazine

: 49584-26-1
p-cyanobenzenesulfonyl chloride

: 1083428-89-0
4-{3-[6-(3,4-dimethoxy-phenyl)-2-methyl-imidazo[1,2-b]pyridazin-3-yl]-pyrazole-1-sulfonyl}-benzonitrile

Guidance literature:: With pyridine; at 20 ℃; for 6h; Neat (no solvent);

Reference yield:

: 122775-35-3
3,4-Dimethoxyphenylboronic acid

: 1083428-89-0
4-{3-[6-(3,4-dimethoxy-phenyl)-2-methyl-imidazo[1,2-b]pyridazin-3-yl]-pyrazole-1-sulfonyl}-benzonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / bis-triphenylphosphine-palladium(II) chloride / water; N,N-dimethyl-formamide / 20 h / 105 °C

2: ethanol / 3.5 h / 150 °C / Microwave irradiation

3: 4 h / 145 °C / Neat (no solvent); Microwave irradiation

4: hydrazine hydrochloride / ethanol / 0.25 h / 120 °C

5: pyridine / 6 h / 20 °C / Neat (no solvent)

With pyridine; hydrazine hydrochloride; potassium carbonate; bis-triphenylphosphine-palladium(II) chloride; In ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1083429-90-6
1-[6-(3,4-dimethoxy-phenyl)-2-methyl-imidazo[1,2-b]pyridazin-3-yl]-ethanone

: 1083428-89-0
4-{3-[6-(3,4-dimethoxy-phenyl)-2-methyl-imidazo[1,2-b]pyridazin-3-yl]-pyrazole-1-sulfonyl}-benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 4 h / 145 °C / Neat (no solvent); Microwave irradiation

2: hydrazine hydrochloride / ethanol / 0.25 h / 120 °C

3: pyridine / 6 h / 20 °C / Neat (no solvent)

With pyridine; hydrazine hydrochloride; In ethanol;