(R)-2-((tert-butyldiphenylsilyl)oxy)-7-((2R,5S)-5-(((tert-butyldiphenylsilyl)oxy)methyl)tetrahydrofuran-2-yl)heptan-1-ol

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Chemical Name:(R)-2-((tert-butyldiphenylsilyl)oxy)-7-((2R,5S)-5-(((tert-butyldiphenylsilyl)oxy)methyl)tetrahydrofuran-2-yl)heptan-1-ol
CAS No.:1371603-73-4
Molecular Formula:C₄₄H₆₀O₄Si₂
Molecular Weight:709.129
Hs Code.:

Synonyms:(R)-2-((tert-butyldiphenylsilyl)oxy)-7-((2R,5S)-5-(((tert-butyldiphenylsilyl)oxy)methyl)tetrahydrofuran-2-yl)heptan-1-ol

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Chemical Property of (R)-2-((tert-butyldiphenylsilyl)oxy)-7-((2R,5S)-5-(((tert-butyldiphenylsilyl)oxy)methyl)tetrahydrofuran-2-yl)heptan-1-ol

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Technology Process of (R)-2-((tert-butyldiphenylsilyl)oxy)-7-((2R,5S)-5-(((tert-butyldiphenylsilyl)oxy)methyl)tetrahydrofuran-2-yl)heptan-1-ol

There total 10 articles about (R)-2-((tert-butyldiphenylsilyl)oxy)-7-((2R,5S)-5-(((tert-butyldiphenylsilyl)oxy)methyl)tetrahydrofuran-2-yl)heptan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₅₂H₆₈O₅Si₂

: 1371603-73-4
(R)-2-((tert-butyldiphenylsilyl)oxy)-7-((2R,5S)-5-(((tert-butyldiphenylsilyl)oxy)methyl)tetrahydrofuran-2-yl)heptan-1-ol

Guidance literature:: With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; at 0 - 20 ℃; for 0.75h; pH=7; aq. phosphate buffer; Inert atmosphere;
DOI:10.1021/jo3004106

Reference yield:

: 214914-86-0
1-(4-Methoxybenzyloxy)pent-4-yn-2-ol

: 1371603-73-4
(R)-2-((tert-butyldiphenylsilyl)oxy)-7-((2R,5S)-5-(((tert-butyldiphenylsilyl)oxy)methyl)tetrahydrofuran-2-yl)heptan-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 18 h / 20 °C / Inert atmosphere

2.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 0.5 h / 20 °C / Inert atmosphere

2.2: 2 h / Inert atmosphere

3.1: 5%-palladium/activated carbon; hydrogen / ethanol / 60 h / 20 °C / 760.05 Torr / Inert atmosphere

4.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 0.75 h / 0 - 20 °C / pH 7 / aq. phosphate buffer; Inert atmosphere

With 1H-imidazole; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; 5%-palladium/activated carbon; hydrogen; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo3004106

Reference yield:

: 1371603-72-3
tert-butyl(((2S,5S)-5-((R,Z)-6-((tert-butyldiphenylsilyl)oxy)-7-((4-methoxybenzyl) oxy)hept-1-en-3-yn-1-yl)tetrahydrofuran-2-yl)methoxy)diphenylsilane

: 1371603-73-4
(R)-2-((tert-butyldiphenylsilyl)oxy)-7-((2R,5S)-5-(((tert-butyldiphenylsilyl)oxy)methyl)tetrahydrofuran-2-yl)heptan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 5%-palladium/activated carbon; hydrogen / ethanol / 60 h / 20 °C / 760.05 Torr / Inert atmosphere

2: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 0.75 h / 0 - 20 °C / pH 7 / aq. phosphate buffer; Inert atmosphere

With 5%-palladium/activated carbon; hydrogen; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In ethanol; dichloromethane;
DOI:10.1021/jo3004106