1-{[(1S,2S,4aR,8aR)-decahydro-2-hydroxy-2-tosyloxymethyl-5,5,8a-trimethylnaphthalen-1-yl]methyl}-2,6-di-O-methoxymethyl-4-methylbenzene

Base Information

• Chemical Name: 1-{[(1S,2S,4aR,8aR)-decahydro-2-hydroxy-2-tosyloxymethyl-5,5,8a-trimethylnaphthalen-1-yl]methyl}-2,6-di-O-methoxymethyl-4-methylbenzene
• CAS No.: 1036709-28-0
• Molecular Formula: C₃₃H₄₈O₈S
• Molecular Weight: 604.805
• Mol file: 1036709-28-0.mol

Synonyms:1-{[(1S,2S,4aR,8aR)-decahydro-2-hydroxy-2-tosyloxymethyl-5,5,8a-trimethylnaphthalen-1-yl]methyl}-2,6-di-O-methoxymethyl-4-methylbenzene

Chemical Property of 1-{[(1S,2S,4aR,8aR)-decahydro-2-hydroxy-2-tosyloxymethyl-5,5,8a-trimethylnaphthalen-1-yl]methyl}-2,6-di-O-methoxymethyl-4-methylbenzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-{[(1S,2S,4aR,8aR)-decahydro-2-hydroxy-2-tosyloxymethyl-5,5,8a-trimethylnaphthalen-1-yl]methyl}-2,6-di-O-methoxymethyl-4-methylbenzene

There total 1 articles about 1-{[(1S,2S,4aR,8aR)-decahydro-2-hydroxy-2-tosyloxymethyl-5,5,8a-trimethylnaphthalen-1-yl]methyl}-2,6-di-O-methoxymethyl-4-methylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1-{[(1S,2S,4aR,8aR)-decahydro-2-hydroxy-2-hydroxy-methyl-5,5,8a-trimethylnaphthalen-1-yl]methyl}-2,6-di-O-methoxymethyl-4-methylbenzene (1036709-27-9) + p-toluenesulfonyl chloride (98-59-9) → 1-{[(1S,2S,4aR,8aR)-decahydro-2-hydroxy-2-tosyloxymethyl-5,5,8a-trimethylnaphthalen-1-yl]methyl}-2,6-di-O-methoxymethyl-4-methylbenzene (1036709-28-0)

Guidance literature:

With pyridine; at 20 ℃; for 4h;

DOI:10.1016/j.tet.2008.03.050

Reference yield: 94.0%

1-{[(1S,2S,4aR,8aR)-decahydro-2-hydroxy-2-tosyloxymethyl-5,5,8a-trimethylnaphthalen-1-yl]methyl}-2,6-di-O-methoxymethyl-4-methylbenzene (1036709-28-0) → 1-{[(1S,2S,4aR,8aR)-decahydro-2-hydroxy-2,5,5,8a-tetramethylnaphthalen-1-yl]methyl}-2,6-di-O-methoxymethyl-4-methylbenzene (1036709-29-1)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 6h; Heating;

DOI:10.1016/j.tet.2008.03.050

upstream raw materials:

1-{[(1S,2S,4aR,8aR)-decahydro-2-hydroxy-2-hydroxy-methyl-5,5,8a-trimethylnaphthalen-1-yl]methyl}-2,6-di-O-methoxymethyl-4-methylbenzene

p-toluenesulfonyl chloride

Downstream raw materials:

1-{[(1S,2S,4aR,8aR)-decahydro-2-hydroxy-2,5,5,8a-tetramethylnaphthalen-1-yl]methyl}-2,6-di-O-methoxymethyl-4-methylbenzene