5'-(4,4'-dimethoxytrityl)-5-(3-trifluoracetylaminopropenyl)-2'-deoxyuridine

Base Information

• Chemical Name: 5'-(4,4'-dimethoxytrityl)-5-(3-trifluoracetylaminopropenyl)-2'-deoxyuridine
• CAS No.: 96102-25-9
• Molecular Formula: C₃₅H₃₄F₃N₃O₈
• Molecular Weight: 681.665

Synonyms:5'-(4,4'-dimethoxytrityl)-5-(3-trifluoracetylaminopropenyl)-2'-deoxyuridine

Chemical Property of 5'-(4,4'-dimethoxytrityl)-5-(3-trifluoracetylaminopropenyl)-2'-deoxyuridine

Chemical Property:

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Technology Process of 5'-(4,4'-dimethoxytrityl)-5-(3-trifluoracetylaminopropenyl)-2'-deoxyuridine

There total 1 articles about 5'-(4,4'-dimethoxytrityl)-5-(3-trifluoracetylaminopropenyl)-2'-deoxyuridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

5-(3'-trifluoroacetamidoallyl)-2'-deoxyuridine (96102-22-6) + 4,4'-dimethoxytrityl chloride (40615-36-9) → 5'-(4,4'-dimethoxytrityl)-5-(3-trifluoracetylaminopropenyl)-2'-deoxyuridine (96102-25-9)

Guidance literature:

With pyridine; at 0 - 20 ℃; for 5h;

Reference yield: 49.7%

5'-(4,4'-dimethoxytrityl)-5-(3-trifluoracetylaminopropenyl)-2'-deoxyuridine (96102-25-9) + 2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine (124482-92-4,89992-70-1) → 3'-β-cyanoethyl-N,N-diisopropylphosphoramidite-5'-(4,4'-dimethoxytrityl)-5-(3-trifluoracetylaminopropenyl)-2'-deoxyuridine

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 0 - 4 ℃; for 0.333333h;

Reference yield:

5'-(4,4'-dimethoxytrityl)-5-(3-trifluoracetylaminopropenyl)-2'-deoxyuridine (96102-25-9) + 4-Oxo-pentanoic acid (2R,3S,5R)-2-[(4-chloro-phenoxy)-hydroxy-phosphoryloxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester (84258-05-9) → C56H56ClF3N5O17P

Guidance literature:

With pyridine; 1-methyl-1H-imidazole; 2,4,6-triisopropylphenylsulfonyl chloride; for 1h;

DOI:10.1016/j.bmc.2008.09.029

upstream raw materials:

5-(3'-trifluoroacetamidoallyl)-2'-deoxyuridine

4,4'-dimethoxytrityl chloride

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