2-acetylamino-3-phenyl-thiopropionic acid S-(2-diphenylphosphanyl-phenyl) ester

Base Information

• Chemical Name: 2-acetylamino-3-phenyl-thiopropionic acid S-(2-diphenylphosphanyl-phenyl) ester
• CAS No.: 289038-94-4
• Molecular Formula: C₂₉H₂₆NO₂PS
• Molecular Weight: 483.571
• Mol file: 289038-94-4.mol

Synonyms:2-acetylamino-3-phenyl-thiopropionic acid S-(2-diphenylphosphanyl-phenyl) ester

Chemical Property of 2-acetylamino-3-phenyl-thiopropionic acid S-(2-diphenylphosphanyl-phenyl) ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 2-acetylamino-3-phenyl-thiopropionic acid S-(2-diphenylphosphanyl-phenyl) ester

There total 1 articles about 2-acetylamino-3-phenyl-thiopropionic acid S-(2-diphenylphosphanyl-phenyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-2-acetylamino-3-phenylpropanoic acid (2018-61-3) → 2-acetylamino-3-phenyl-thiopropionic acid S-(2-diphenylphosphanyl-phenyl) ester (289038-94-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / 1,3-dicyclohexylcarbodiimide / dimethylformamide / 12 h / 20 °C

2: diisopropylethylamine / 12 h

With N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; 1: Addition / 2: Addition;

DOI:10.1021/ol0060174

Reference yield: 35.0%

2-azido-N-(phenylmethyl)acetamide (116433-53-5) + 2-acetylamino-3-phenyl-thiopropionic acid S-(2-diphenylphosphanyl-phenyl) ester (289038-94-4) → AcPheGlyNHBn

Guidance literature:

In tetrahydrofuran; water; at 20 ℃; for 12h;

DOI:10.1021/ol006739v

Reference yield:

2-azido-N-(phenylmethyl)acetamide (116433-53-5) + 2-acetylamino-3-phenyl-thiopropionic acid S-(2-diphenylphosphanyl-phenyl) ester (289038-94-4) → 2-(Diphenyl-phosphinoyl)-benzenethiol (119327-20-7) + AcPheGlyNHBn

Guidance literature:

2-azido-N-(phenylmethyl)acetamide; 2-acetylamino-3-phenyl-thiopropionic acid S-(2-diphenylphosphanyl-phenyl) ester; In tetrahydrofuran; water; at 20 ℃; for 16h;

With hydrogenchloride; In tetrahydrofuran; water; Further stages.;

DOI:10.1021/ol0060174

upstream raw materials:

(S)-2-acetylamino-3-phenylpropanoic acid

Downstream raw materials:

2-(Diphenyl-phosphinoyl)-benzenethiol