6-(dimethylamino)-9-<3'-<amino>-3'-deoxy-β-D-ribofuranosyl>purine

Base Information

Chemical Name:6-(dimethylamino)-9-<3'-<amino>-3'-deoxy-β-D-ribofuranosyl>purine
CAS No.:76381-69-6
Molecular Formula:C₂₈H₃₈N₈O₇
Molecular Weight:598.659
Hs Code.:

6-(dimethylamino)-9-<3'-<<N-(tert-butyloxycarbonyl)-p-acetamido-L-phenylalanyl>amino>-3'-deoxy-β-D-ribofuranosyl>purine

Synonyms:6-(dimethylamino)-9-<3'-<amino>-3'-deoxy-β-D-ribofuranosyl>purine

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Chemical Property of 6-(dimethylamino)-9-<3'-<amino>-3'-deoxy-β-D-ribofuranosyl>purine

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Technology Process of 6-(dimethylamino)-9-<3'-<amino>-3'-deoxy-β-D-ribofuranosyl>purine

There total 5 articles about 6-(dimethylamino)-9-<3'-<amino>-3'-deoxy-β-D-ribofuranosyl>purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.3%

: 14464-29-0,57212-69-8
N-acetoxysuccinimide

: 76494-20-7
6-(dimethylamino)-9-<3'-<amino>-3'-deoxy-β-D-ribofuranosyl>purine

: 76381-69-6
6-(dimethylamino)-9-<3'-<amino>-3'-deoxy-β-D-ribofuranosyl>purine

Guidance literature:: In 1,4-dioxane; for 72h; Ambient temperature;
DOI:10.1021/jm00135a013

Reference yield:

: 1070-19-5
N-(tert-butyloxycarbonyl) azide

: 76381-69-6
6-(dimethylamino)-9-<3'-<amino>-3'-deoxy-β-D-ribofuranosyl>purine

Guidance literature:: Multi-step reaction with 4 steps

1: 44 percent / magnesium hydroxide / H₂O; dioxane / 20 h / 40 °C

2: 70.5 percent / N-hydroxysuccinimide, dicyclohexylcarbodiimide / dimethylformamide / 20 h / Ambient temperature

3: 88.3 percent / H₂, glacial CH₃COOH / 10percent Pd/C / 4 h / 760 Torr / Ambient temperature

4: 69.3 percent / dioxane / 72 h / Ambient temperature

With magnesium hydroxide; 1-hydroxy-pyrrolidine-2,5-dione; hydrogen; acetic acid; dicyclohexyl-carbodiimide; palladium on activated charcoal; In 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00135a013

Reference yield:

: 949-99-5
4-nitro-3-phenyl-L-alanine

: 76381-69-6
6-(dimethylamino)-9-<3'-<amino>-3'-deoxy-β-D-ribofuranosyl>purine

Guidance literature:: Multi-step reaction with 4 steps

1: 44 percent / magnesium hydroxide / H₂O; dioxane / 20 h / 40 °C

2: 70.5 percent / N-hydroxysuccinimide, dicyclohexylcarbodiimide / dimethylformamide / 20 h / Ambient temperature

3: 88.3 percent / H₂, glacial CH₃COOH / 10percent Pd/C / 4 h / 760 Torr / Ambient temperature

4: 69.3 percent / dioxane / 72 h / Ambient temperature

With magnesium hydroxide; 1-hydroxy-pyrrolidine-2,5-dione; hydrogen; acetic acid; dicyclohexyl-carbodiimide; palladium on activated charcoal; In 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00135a013