[2-(trimethylsilyl)ethyl] 3-(4'-benzyloxy)benzoyl-5-cyanobenzoate

Base Information

Chemical Name:[2-(trimethylsilyl)ethyl] 3-(4'-benzyloxy)benzoyl-5-cyanobenzoate
CAS No.:301355-98-6
Molecular Formula:C₂₇H₂₇NO₄Si
Molecular Weight:457.601
Hs Code.:

Synonyms:[2-(trimethylsilyl)ethyl] 3-(4'-benzyloxy)benzoyl-5-cyanobenzoate

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Chemical Property of [2-(trimethylsilyl)ethyl] 3-(4'-benzyloxy)benzoyl-5-cyanobenzoate

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Technology Process of [2-(trimethylsilyl)ethyl] 3-(4'-benzyloxy)benzoyl-5-cyanobenzoate

There total 8 articles about [2-(trimethylsilyl)ethyl] 3-(4'-benzyloxy)benzoyl-5-cyanobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 557-21-1
dicyanozinc

: 301355-97-5
[2-(trimethylsilyl)ethyl] 3-(4'-benzyloxy)benzoyl-5-bromobenzoate

: 301355-98-6
[2-(trimethylsilyl)ethyl] 3-(4'-benzyloxy)benzoyl-5-cyanobenzoate

Guidance literature:: tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 80 ℃; for 6h;
DOI:10.1016/S0968-0896(00)00169-3

Reference yield:

: 2916-68-9
2-(Trimethylsilyl)ethanol

: 301355-98-6
[2-(trimethylsilyl)ethyl] 3-(4'-benzyloxy)benzoyl-5-cyanobenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: 69 percent / dppp; Et₃N / Pd(OAc)2 / dimethylformamide / 20 - 85 °C

2: 87 percent / Pd(PPh₃)4 / dimethylformamide / 6 h / 80 °C

With 1,3-bis-(diphenylphosphino)propane; triethylamine; palladium diacetate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; 1: Carboxylation / 2: Substitution;
DOI:10.1016/S0968-0896(00)00169-3

Reference yield:

: 188815-32-9
3-bromo-5-iodo-benzoic acid

: 301355-98-6
[2-(trimethylsilyl)ethyl] 3-(4'-benzyloxy)benzoyl-5-cyanobenzoate

Guidance literature:: Multi-step reaction with 5 steps

1: 73 percent / DCC; DMAP / diethyl ether / 0 - 20 °C

2: AlCl₃ / 0.5 h / 145 °C

3: 1.10 g / K₂CO₃ / acetone / 5 h / Heating

4: 69 percent / dppp; Et₃N / Pd(OAc)2 / dimethylformamide / 20 - 85 °C

5: 87 percent / Pd(PPh₃)4 / dimethylformamide / 6 h / 80 °C

With dmap; aluminium trichloride; 1,3-bis-(diphenylphosphino)propane; potassium carbonate; triethylamine; dicyclohexyl-carbodiimide; palladium diacetate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In diethyl ether; N,N-dimethyl-formamide; acetone; 1: Esterification / 2: Fries reaction / 3: Substitution / 4: Carboxylation / 5: Substitution;
DOI:10.1016/S0968-0896(00)00169-3