Methyl (E)-N-(Diphenylmethylene)-α,β-didehydro-β-methylalaninate

Base Information

• Chemical Name: Methyl (E)-N-(Diphenylmethylene)-α,β-didehydro-β-methylalaninate
• CAS No.: 120238-58-6
• Molecular Formula: C₁₈H₁₇NO₂
• Molecular Weight: 279.338
• Mol file: 120238-58-6.mol

Synonyms:Methyl (E)-N-(Diphenylmethylene)-α,β-didehydro-β-methylalaninate

Chemical Property of Methyl (E)-N-(Diphenylmethylene)-α,β-didehydro-β-methylalaninate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methyl (E)-N-(Diphenylmethylene)-α,β-didehydro-β-methylalaninate

There total 2 articles about Methyl (E)-N-(Diphenylmethylene)-α,β-didehydro-β-methylalaninate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

N-diphenylmethylene-L-threonine methyl ester (130740-27-1) → Methyl (E)-N-(Diphenylmethylene)-α,β-didehydro-β-methylalaninate (120238-58-6)

Guidance literature:

With diisopropyl-carbodiimide; copper(l) chloride; In dichloromethane; at 40 ℃; for 32h;

DOI:10.1055/s-1990-27012

Reference yield: 22.0%

Methyl (Z)-N-(Diphenylmethylene)-α,β-didehydro-β-methylalaninate (120238-59-7) → Methyl (E)-N-(Diphenylmethylene)-α,β-didehydro-β-methylalaninate (120238-58-6) + 2-(Benzhydrylidene-amino)-but-3-enoic acid methyl ester (133559-28-1)

Guidance literature:

With acetic acid; lithium diisopropyl amide; In tetrahydrofuran; -50 deg C then -70 deg C;

DOI:10.1016/S0040-4020(01)86055-5

Reference yield: 100.0%

Methyl (E)-N-(Diphenylmethylene)-α,β-didehydro-β-methylalaninate (120238-58-6) → Methyl (Z)-N-(Diphenylmethylene)-α,β-didehydro-β-methylalaninate (120238-59-7)

Guidance literature:

With water; lithium diisopropyl amide; In tetrahydrofuran; -50 deg C then 20 deg C;

DOI:10.1016/S0040-4020(01)86055-5

upstream raw materials:

Methyl (Z)-N-(Diphenylmethylene)-α,β-didehydro-β-methylalaninate

N-diphenylmethylene-L-threonine methyl ester

Downstream raw materials:

(2RS,3RS)-methyl N-(diphenylmethylene)-β-methyltryptophanate

(2SR,3RS)-methyl N-(diphenylmethylene)-β-methyltryptophanate

(2RS,3RS)-methyl N-(diphenylmethylene)-β-methyl-5-methyltryptophanate

(2SR,3RS)-methyl N-(diphenylmethylene)-β-methyl-5-methyltryptophanate