ethyl 3-(4-(trifluoromethyl)phenyl)imidazo[1,5-α]pyridine-1-carboxylate

Base Information

Chemical Name:ethyl 3-(4-(trifluoromethyl)phenyl)imidazo[1,5-α]pyridine-1-carboxylate
CAS No.:1430074-80-8
Molecular Formula:C₁₇H₁₃F₃N₂O₂
Molecular Weight:334.298
Hs Code.:

Synonyms:ethyl 3-(4-(trifluoromethyl)phenyl)imidazo[1,5-α]pyridine-1-carboxylate

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Chemical Property of ethyl 3-(4-(trifluoromethyl)phenyl)imidazo[1,5-α]pyridine-1-carboxylate

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Technology Process of ethyl 3-(4-(trifluoromethyl)phenyl)imidazo[1,5-α]pyridine-1-carboxylate

There total 5 articles about ethyl 3-(4-(trifluoromethyl)phenyl)imidazo[1,5-α]pyridine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 2739-98-2
ethyl 2-(pyridinyl-2)acetate

: 3300-51-4
p-Trifluoromethylbenzylamine

: 1430074-80-8
ethyl 3-(4-(trifluoromethyl)phenyl)imidazo[1,5-α]pyridine-1-carboxylate

Guidance literature:: With tert.-butylhydroperoxide; N-iodo-succinimide; In N,N-dimethyl acetamide; water; at 20 ℃; for 12h;
DOI:10.1021/ol4008487

Reference yield:

: 2739-98-2
ethyl 2-(pyridinyl-2)acetate

: 1430074-80-8
ethyl 3-(4-(trifluoromethyl)phenyl)imidazo[1,5-α]pyridine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium nitrite / 2 h / 0 - 20 °C

2: 5%-palladium/activated carbon / methanol / 3 h / 20 °C

3: triethylamine / tetrahydrofuran / 2 h / 0 - 20 °C

4: trichlorophosphate / 4 h / 120 °C

With 5%-palladium/activated carbon; triethylamine; sodium nitrite; trichlorophosphate; In tetrahydrofuran; methanol;
DOI:10.1039/c2md20219k

Reference yield:

: 71721-67-0
ethyl 2-hydroxyimino-2-(pyridin-2-yl)acetate

: 1430074-80-8
ethyl 3-(4-(trifluoromethyl)phenyl)imidazo[1,5-α]pyridine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 5%-palladium/activated carbon / methanol / 3 h / 20 °C

2: triethylamine / tetrahydrofuran / 2 h / 0 - 20 °C

3: trichlorophosphate / 4 h / 120 °C

With 5%-palladium/activated carbon; triethylamine; trichlorophosphate; In tetrahydrofuran; methanol;
DOI:10.1039/c2md20219k