5'-(N-benzyloxycarbonyl-O-tert-butoxycarbonyl)hydroxyamino-3-N-benzyloxymethyl-5'-deoxy-2'-O-methanesulfonyluridine

Base Information

• Chemical Name: 5'-(N-benzyloxycarbonyl-O-tert-butoxycarbonyl)hydroxyamino-3-N-benzyloxymethyl-5'-deoxy-2'-O-methanesulfonyluridine
• CAS No.: 1138083-37-0
• Molecular Formula: C₃₁H₃₇N₃O₁₃S
• Molecular Weight: 691.713
• Mol file: 1138083-37-0.mol

Synonyms:5'-(N-benzyloxycarbonyl-O-tert-butoxycarbonyl)hydroxyamino-3-N-benzyloxymethyl-5'-deoxy-2'-O-methanesulfonyluridine

Chemical Property of 5'-(N-benzyloxycarbonyl-O-tert-butoxycarbonyl)hydroxyamino-3-N-benzyloxymethyl-5'-deoxy-2'-O-methanesulfonyluridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5'-(N-benzyloxycarbonyl-O-tert-butoxycarbonyl)hydroxyamino-3-N-benzyloxymethyl-5'-deoxy-2'-O-methanesulfonyluridine

There total 1 articles about 5'-(N-benzyloxycarbonyl-O-tert-butoxycarbonyl)hydroxyamino-3-N-benzyloxymethyl-5'-deoxy-2'-O-methanesulfonyluridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

benzyl ((tert-butoxycarbonyl)oxy)carbamate (1138083-43-8) + 3-N-benzyloxymethyl-2'-O-methanesulfonyluridine (1080623-49-9) → 5'-(N-benzyloxycarbonyl-O-tert-butoxycarbonyl)hydroxyamino-3-N-benzyloxymethyl-5'-deoxy-2'-O-methanesulfonyluridine (1138083-37-0)

Guidance literature:

With di-tert-butyl-diazodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1016/j.tet.2008.12.073

Reference yield:

5'-(N-benzyloxycarbonyl-O-tert-butoxycarbonyl)hydroxyamino-3-N-benzyloxymethyl-5'-deoxy-2'-O-methanesulfonyluridine (1138083-37-0) + tert-butylchlorodiphenylsilane (58479-61-1) → C47H55N3O13SSi

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1016/j.tet.2008.12.073

upstream raw materials:

benzyl ((tert-butoxycarbonyl)oxy)carbamate

3-N-benzyloxymethyl-2'-O-methanesulfonyluridine

Refernces