(±)-(E)-3-[1'-(2-phenylethyl)-4-oxospiro(chromane-2,4’-azepane)-6-yl]-N-hydroxyacrylamide trifluoroacetate

Base Information

Chemical Name:(±)-(E)-3-[1'-(2-phenylethyl)-4-oxospiro(chromane-2,4’-azepane)-6-yl]-N-hydroxyacrylamide trifluoroacetate
CAS No.:1291077-40-1
Molecular Formula:C₂HF₃O₂*C₂₅H₂₈N₂O₄
Molecular Weight:534.532
Hs Code.:

Synonyms:(±)-(E)-3-[1'-(2-phenylethyl)-4-oxospiro(chromane-2,4’-azepane)-6-yl]-N-hydroxyacrylamide trifluoroacetate

Suppliers and Price of (±)-(E)-3-[1'-(2-phenylethyl)-4-oxospiro(chromane-2,4’-azepane)-6-yl]-N-hydroxyacrylamide trifluoroacetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (±)-(E)-3-[1'-(2-phenylethyl)-4-oxospiro(chromane-2,4’-azepane)-6-yl]-N-hydroxyacrylamide trifluoroacetate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (±)-(E)-3-[1'-(2-phenylethyl)-4-oxospiro(chromane-2,4’-azepane)-6-yl]-N-hydroxyacrylamide trifluoroacetate

There total 8 articles about (±)-(E)-3-[1'-(2-phenylethyl)-4-oxospiro(chromane-2,4’-azepane)-6-yl]-N-hydroxyacrylamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 1291077-43-4
(E)-3-[1'-(2-phenyl-ethyl)-4-oxo-spiro(chromane-2,4'-azepane)-6-yl]-N-(tetrahydro-pyran-2-yloxy)-acrylamide

: 76-05-1
trifluoroacetic acid

: 1291077-40-1
(±)-(E)-3-[1'-(2-phenylethyl)-4-oxospiro(chromane-2,4’-azepane)-6-yl]-N-hydroxyacrylamide trifluoroacetate

Guidance literature:: (E)-3-[1'-(2-phenyl-ethyl)-4-oxo-spiro(chromane-2,4'-azepane)-6-yl]-N-(tetrahydro-pyran-2-yloxy)-acrylamide; With hydrogenchloride; water; In diethyl ether; dichloromethane; at 20 ℃; for 1h;

trifluoroacetic acid; In water; acetonitrile;
DOI:10.1016/j.ejmech.2015.11.010

Reference yield:

: 1291076-33-9
(±)-6-bromo-4-oxospiro[chromane-2,4'-azepane-6-yl]-1'-carboxylic acid tert-butyl ester

: 1291077-40-1
(±)-(E)-3-[1'-(2-phenylethyl)-4-oxospiro(chromane-2,4’-azepane)-6-yl]-N-hydroxyacrylamide trifluoroacetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: tris-(o-tolyl)phosphine; palladium diacetate; triethylamine / N,N-dimethyl-formamide / 3 h / 100 °C / Inert atmosphere

2.1: water; hydrogenchloride / dichloromethane; 1,4-dioxane / 1 h / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 360 h / 20 °C

4.1: water; acetic acid; hydrogenchloride / 3 h / 85 °C

5.1: triethylamine / dichloromethane / 0 °C

5.2: 3 h

5.3: 20 °C

6.1: water; hydrogenchloride / dichloromethane; diethyl ether / 1 h / 20 °C

With hydrogenchloride; water; palladium diacetate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; tris-(o-tolyl)phosphine; In 1,4-dioxane; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2015.11.010

Reference yield:

: 188975-88-4
tert-butyl 4-oxoazepane-1-carboxylate

: 1291077-40-1
(±)-(E)-3-[1'-(2-phenylethyl)-4-oxospiro(chromane-2,4’-azepane)-6-yl]-N-hydroxyacrylamide trifluoroacetate

Guidance literature:: Multi-step reaction with 7 steps

1.1: pyrrolidine / methanol / 4 h / 70 °C / Microwave irradiation

2.1: tris-(o-tolyl)phosphine; palladium diacetate; triethylamine / N,N-dimethyl-formamide / 3 h / 100 °C / Inert atmosphere

3.1: water; hydrogenchloride / dichloromethane; 1,4-dioxane / 1 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 360 h / 20 °C

5.1: water; acetic acid; hydrogenchloride / 3 h / 85 °C

6.1: triethylamine / dichloromethane / 0 °C

6.2: 3 h

6.3: 20 °C

7.1: water; hydrogenchloride / dichloromethane; diethyl ether / 1 h / 20 °C

With pyrrolidine; hydrogenchloride; water; palladium diacetate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; tris-(o-tolyl)phosphine; In 1,4-dioxane; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2015.11.010