2-Chloro-4-bromobenzaldehyde

Base Information

• Chemical Name: 2-Chloro-4-bromobenzaldehyde
• CAS No.: 158435-41-7
• Molecular Formula: C7H4BrClO
• Molecular Weight: 219.465
• Hs Code.: 2913000090
• Mol file: 158435-41-7.mol

Synonyms:4-Bromo-2-chlorobenzaldehyde;

Chemical Property of 2-Chloro-4-bromobenzaldehyde

Chemical Property:

• Vapor Pressure: 0.0065mmHg at 25°C
• Melting Point: 74-76℃
• Refractive Index: 1.623
• Boiling Point: 271.3 °C at 760 mmHg
• Flash Point: 117.9 °C
• PSA: 17.07000
• Density: 1.698 g/cm³
• LogP: 2.91500
• Storage Temp.: Refrigerated.
• Sensitive.: Air Sensitive
• Solubility.: soluble in Methanol

Purity/Quality:

99.9% ^*data from raw suppliers

4-Bromo-2-chlorobenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C,Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Chloro-4-bromobenzaldehyde

There total 12 articles about 2-Chloro-4-bromobenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-bromo-2-chloro-1-(dibromomethyl)benzene (960053-48-9) → 4-bromo-2-chlorobenzaldehyde (158435-41-7)

Guidance literature:

With silver nitrate; In ethanol; water; for 1.33333h; Reflux;

Reference yield: 96.0%

(4-bromo-2-chlorophenyl)methanol (185315-48-4) → 4-bromo-2-chlorobenzaldehyde (158435-41-7)

Guidance literature:

(4-bromo-2-chlorophenyl)methanol; With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -78 ℃; for 2h;

With triethylamine; In dichloromethane; at 20 ℃; for 0.5h;

Reference yield: 67.0%

4-bromo-2-chloroiodobenzene (31928-47-9) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 4-bromo-2-chlorobenzaldehyde (158435-41-7)

Guidance literature:

4-bromo-2-chloroiodobenzene; With isopropylmagnesium chloride; In tetrahydrofuran; at -70 - -60 ℃; for 0.166667h;

N,N-dimethyl-formamide; In tetrahydrofuran; at -60 - 20 ℃; for 1h;

DOI:10.1016/j.bmcl.2012.04.019

upstream raw materials:

4-bromo-2-chloro-1-(dibromomethyl)benzene

(4-bromo-2-chlorophenyl)methanol

4-bromo-2-chlorobenzonitrile

4-bromo-2-chloroiodobenzene

Downstream raw materials:

(R)-N-(4-bromo-2-chlorobenzylidene)-2-methylpropane-2-sulfinamide

4-bromo-2-chloro-1-((E)-2-nitro-propenyl)-benzene

1-(4-bromo-2-chlorobenzyl)piperidine

3-chloro-(1,1'-biphenyl)-4-carbaldehyde

Refernces

• 1、 Liu, Xi-Hai,Park, Hojoon,Hu, Jun-Hao,Hu, Yan,Zhang, Qun-Liang,Wang, Bao-Long,Sun, Bing,Yeung, Kap-Sun,Zhang, Fang-Lin,Yu, Jin-Quan. "Diverse ortho-C(sp2)-H functionalization of benzaldehydes using transient directing groups". supporting information. p. 888 - 896. Retrieved 2017/05/16.
• 2、 -. "2- PYRIDONE COMPOUND". . . Retrieved 2016/10/08.