4-(2-fluorophenyl)-7-methyl-6-(pyrimidin-5-yloxy)-9H-pyrido[3,4-b]indole-1-carboxylic acid

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Chemical Name:4-(2-fluorophenyl)-7-methyl-6-(pyrimidin-5-yloxy)-9H-pyrido[3,4-b]indole-1-carboxylic acid
CAS No.:1352834-88-8
Molecular Formula:C₂₃H₁₅FN₄O₃
Molecular Weight:414.396
Hs Code.:

Synonyms:4-(2-fluorophenyl)-7-methyl-6-(pyrimidin-5-yloxy)-9H-pyrido[3,4-b]indole-1-carboxylic acid

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Chemical Property of 4-(2-fluorophenyl)-7-methyl-6-(pyrimidin-5-yloxy)-9H-pyrido[3,4-b]indole-1-carboxylic acid

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Technology Process of 4-(2-fluorophenyl)-7-methyl-6-(pyrimidin-5-yloxy)-9H-pyrido[3,4-b]indole-1-carboxylic acid

There total 8 articles about 4-(2-fluorophenyl)-7-methyl-6-(pyrimidin-5-yloxy)-9H-pyrido[3,4-b]indole-1-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.9%

: 1352834-87-7
ethyl 4-(2-fluorophenyl)-7-methyl-6-(pyrimidin-5-yloxy)-9H-pyrido[3,4-b]indole-1-carboxylate

: 1352834-88-8
4-(2-fluorophenyl)-7-methyl-6-(pyrimidin-5-yloxy)-9H-pyrido[3,4-b]indole-1-carboxylic acid

Guidance literature:: ethyl 4-(2-fluorophenyl)-7-methyl-6-(pyrimidin-5-yloxy)-9H-pyrido[3,4-b]indole-1-carboxylate; With water; sodium hydroxide; In methanol; for 1h; Reflux;

In water; pH=~ 4;

Reference yield:

: 553-94-6
4-bromo-m-xylene

: 1352834-88-8
4-(2-fluorophenyl)-7-methyl-6-(pyrimidin-5-yloxy)-9H-pyrido[3,4-b]indole-1-carboxylic acid

Guidance literature:: Multi-step reaction with 8 steps

1.1: nitric acid; sulfuric acid; acetic acid / 1.75 h / 8 - 10 °C

2.1: caesium carbonate / copper(l) chloride; 2,2,6,6-tetramethylheptane-3,5-dione / 1-methyl-pyrrolidin-2-one / 130 °C / Sealed tube

3.1: N,N-dimethyl-formamide / 0.75 h / 115 °C / Inert atmosphere

4.1: hydrogen / palladium 10% on activated carbon / methanol

5.1: 4 h / 130 °C

6.1: hydrogen / Raney Ni / methanol / 3 h / 2740.96 Torr

7.1: hydrogenchloride / toluene; 1,4-dioxane / Inert atmosphere

7.2: pH ~ 12

7.3: 0.75 h / Reflux

8.1: sodium hydroxide; water / methanol / 1 h / Reflux

8.2: pH ~ 4

With hydrogenchloride; sulfuric acid; water; hydrogen; nitric acid; caesium carbonate; acetic acid; sodium hydroxide; 2,2,6,6-tetramethylheptane-3,5-dione; palladium 10% on activated carbon; copper(l) chloride; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; N,N-dimethyl-formamide; toluene;

Reference yield:

: 15540-81-5
1-bromo-2,5-dimethyl-4-nitrobenzene

: 1352834-88-8
4-(2-fluorophenyl)-7-methyl-6-(pyrimidin-5-yloxy)-9H-pyrido[3,4-b]indole-1-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: caesium carbonate / copper(l) chloride; 2,2,6,6-tetramethylheptane-3,5-dione / 1-methyl-pyrrolidin-2-one / 130 °C / Sealed tube

2.1: N,N-dimethyl-formamide / 0.75 h / 115 °C / Inert atmosphere

3.1: hydrogen / palladium 10% on activated carbon / methanol

4.1: 4 h / 130 °C

5.1: hydrogen / Raney Ni / methanol / 3 h / 2740.96 Torr

6.1: hydrogenchloride / toluene; 1,4-dioxane / Inert atmosphere

6.2: pH ~ 12

6.3: 0.75 h / Reflux

7.1: sodium hydroxide; water / methanol / 1 h / Reflux

7.2: pH ~ 4

With hydrogenchloride; water; hydrogen; caesium carbonate; sodium hydroxide; 2,2,6,6-tetramethylheptane-3,5-dione; palladium 10% on activated carbon; copper(l) chloride; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; N,N-dimethyl-formamide; toluene;