{4-[(S)-2-Amino-2-(1-{(S)-2-carbamoyl-1-[3-(5-methyl-indol-1-yl)-propylcarbamoyl]-ethylcarbamoyl}-cyclohexylcarbamoyl)-ethyl]-benzyl}-phosphonic acid di-tert-butyl ester

Base Information

• Chemical Name: {4-[(S)-2-Amino-2-(1-{(S)-2-carbamoyl-1-[3-(5-methyl-indol-1-yl)-propylcarbamoyl]-ethylcarbamoyl}-cyclohexylcarbamoyl)-ethyl]-benzyl}-phosphonic acid di-tert-butyl ester
• CAS No.: 264131-79-5
• Molecular Formula: C₄₁H₆₁N₆O₇P
• Molecular Weight: 780.945
• Mol file: 264131-79-5.mol

Synonyms:{4-[(S)-2-Amino-2-(1-{(S)-2-carbamoyl-1-[3-(5-methyl-indol-1-yl)-propylcarbamoyl]-ethylcarbamoyl}-cyclohexylcarbamoyl)-ethyl]-benzyl}-phosphonic acid di-tert-butyl ester

Chemical Property of {4-[(S)-2-Amino-2-(1-{(S)-2-carbamoyl-1-[3-(5-methyl-indol-1-yl)-propylcarbamoyl]-ethylcarbamoyl}-cyclohexylcarbamoyl)-ethyl]-benzyl}-phosphonic acid di-tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {4-[(S)-2-Amino-2-(1-{(S)-2-carbamoyl-1-[3-(5-methyl-indol-1-yl)-propylcarbamoyl]-ethylcarbamoyl}-cyclohexylcarbamoyl)-ethyl]-benzyl}-phosphonic acid di-tert-butyl ester

There total 6 articles about {4-[(S)-2-Amino-2-(1-{(S)-2-carbamoyl-1-[3-(5-methyl-indol-1-yl)-propylcarbamoyl]-ethylcarbamoyl}-cyclohexylcarbamoyl)-ethyl]-benzyl}-phosphonic acid di-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

{4-[2-(1-{2-carbamoyl-1-[3-(5-methyl-indol-1-yl)-propylcarbamoyl]-ethylcarbamoyl}-cyclohexylcarbamoyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-ethyl]-benzyl}-phosphonic acid di-tert-butyl ester (264131-78-4) → {4-[(S)-2-Amino-2-(1-{(S)-2-carbamoyl-1-[3-(5-methyl-indol-1-yl)-propylcarbamoyl]-ethylcarbamoyl}-cyclohexylcarbamoyl)-ethyl]-benzyl}-phosphonic acid di-tert-butyl ester (264131-79-5)

Guidance literature:

In acetonitrile; at 20 ℃; for 3h;

DOI:10.1021/jm9904248

Reference yield:

L-Nα-(9-fluorenylmethoxycarbonyloxy)-4-[(di-tert-butyl)phosphonomethyl]phenylalanine (166409-77-4) → {4-[(S)-2-Amino-2-(1-{(S)-2-carbamoyl-1-[3-(5-methyl-indol-1-yl)-propylcarbamoyl]-ethylcarbamoyl}-cyclohexylcarbamoyl)-ethyl]-benzyl}-phosphonic acid di-tert-butyl ester (264131-79-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: HOBt*H₂O; DIPCDI / dimethylformamide / 0.17 h / 20 °C

1.2: 52 percent / dimethylformamide / 20 °C

2.1: acetonitrile / 3 h / 20 °C

With 1,3-di-tert-butylcarbodiimide; benzotriazol-1-ol; In N,N-dimethyl-formamide; acetonitrile; 1.1: Condensation / 1.2: Condensation / 2.1: Deprotection;

DOI:10.1021/jm9904248

Reference yield:

1-[((9H-fluoren-9-yl)methoxy)carbonylamino]cyclohexanecarboxylic acid (162648-54-6) → {4-[(S)-2-Amino-2-(1-{(S)-2-carbamoyl-1-[3-(5-methyl-indol-1-yl)-propylcarbamoyl]-ethylcarbamoyl}-cyclohexylcarbamoyl)-ethyl]-benzyl}-phosphonic acid di-tert-butyl ester (264131-79-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: HOBt*H₂O; DIPCDI / dimethylformamide / 1 h / 20 °C

1.2: 96 percent / dimethylformamide / 20 °C

2.1: piperidine / dimethylformamide

3.1: HOBt*H₂O; DIPCDI / dimethylformamide / 0.17 h / 20 °C

3.2: 52 percent / dimethylformamide / 20 °C

4.1: acetonitrile / 3 h / 20 °C

With piperidine; 1,3-di-tert-butylcarbodiimide; benzotriazol-1-ol; In N,N-dimethyl-formamide; acetonitrile; 1.1: Condensation / 1.2: Condensation / 2.1: Deprotection / 3.1: Condensation / 3.2: Condensation / 4.1: Deprotection;

DOI:10.1021/jm9904248

upstream raw materials:

{4-[2-(1-{2-carbamoyl-1-[3-(5-methyl-indol-1-yl)-propylcarbamoyl]-ethylcarbamoyl}-cyclohexylcarbamoyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-ethyl]-benzyl}-phosphonic acid di-tert-butyl ester

L-N_α-(9-fluorenylmethoxycarbonyloxy)-4-[(di-tert-butyl)phosphonomethyl]phenylalanine

1-[((9H-fluoren-9-yl)methoxy)carbonylamino]cyclohexanecarboxylic acid

2-[(1-amino-cyclohexanecarbonyl)-amino]-N¹-[3-(5-methyl-indol-1-yl)-propyl]-succinamide

Downstream raw materials:

{4-[(S)-2-Acetylamino-2-(1-{(S)-2-carbamoyl-1-[3-(5-methyl-indol-1-yl)-propylcarbamoyl]-ethylcarbamoyl}-cyclohexylcarbamoyl)-ethyl]-benzyl}-phosphonic acid di-tert-butyl ester

N-{1-(1-{2-carbamoyl-1-[3-(5-methyl-indol-1-yl)-propylcarbamoyl]-ethylcarbamoyl}-cyclohexylcarbamoyl)-2-[4-(di-tert-butoxy-phosphorylmethyl)-phenyl]-ethyl}-oxalamic acid tert-butyl ester