4-methylbenzyl 1-[4-(pyrimidin-2-yl)aminomethyl-1,2,5,6-tetrahydro-pyridin-1-yl]carboxylate

Base Information

Chemical Name:4-methylbenzyl 1-[4-(pyrimidin-2-yl)aminomethyl-1,2,5,6-tetrahydro-pyridin-1-yl]carboxylate
CAS No.:1383483-81-5
Molecular Formula:C₁₉H₂₂N₄O₂
Molecular Weight:338.409
Hs Code.:

Synonyms:4-methylbenzyl 1-[4-(pyrimidin-2-yl)aminomethyl-1,2,5,6-tetrahydro-pyridin-1-yl]carboxylate

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Chemical Property of 4-methylbenzyl 1-[4-(pyrimidin-2-yl)aminomethyl-1,2,5,6-tetrahydro-pyridin-1-yl]carboxylate

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Technology Process of 4-methylbenzyl 1-[4-(pyrimidin-2-yl)aminomethyl-1,2,5,6-tetrahydro-pyridin-1-yl]carboxylate

There total 25 articles about 4-methylbenzyl 1-[4-(pyrimidin-2-yl)aminomethyl-1,2,5,6-tetrahydro-pyridin-1-yl]carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (±)-cis-4-methylbenzyl 1-[4-(pyrimidin-2-yl)aminomethyl-3-(methylsulfonyl)hydroxypiperidin-1-yl] carboxylate

: 1383483-81-5
4-methylbenzyl 1-[4-(pyrimidin-2-yl)aminomethyl-1,2,5,6-tetrahydro-pyridin-1-yl]carboxylate

: (+/-)-trans-4-methylbenzyl 1-[3-(⁽¹⁸⁾F)fluoro-4-(pyrimidin-2-ylamino)methylpiperidin-1-yl]carboxylate

Guidance literature:: With [¹⁸F]-potassium fluoride; potassium carbonate; [2.2.2]cryptande; In acetonitrile; for 0.333333h; Heating;
DOI:10.1016/j.ejmech.2012.04.011

Reference yield:

: (±)-trans-4-methylbenzyl 1-[4-(pyrimidin-2-yl)aminomethyl-3-(methylsulfonyl)hydroxypiperidin-1-yl] carboxylate

: 1383483-81-5
4-methylbenzyl 1-[4-(pyrimidin-2-yl)aminomethyl-1,2,5,6-tetrahydro-pyridin-1-yl]carboxylate

: (+/-)-cis-4-methylbenzyl 1-[3-(⁽¹⁸⁾F)fluoro-4-(pyrimidin-2-ylamino)methylpiperidin-1-yl]carboxylate

Guidance literature:: With [¹⁸F]-potassium fluoride; potassium carbonate; [2.2.2]cryptande; In acetonitrile; for 0.333333h; Heating;
DOI:10.1016/j.ejmech.2012.04.011

Reference yield:

: C₁₁H₂₂N₂O₃

: 1383483-81-5
4-methylbenzyl 1-[4-(pyrimidin-2-yl)aminomethyl-1,2,5,6-tetrahydro-pyridin-1-yl]carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine / tert-Amyl alcohol / 48 h / 90 °C / Inert atmosphere

2: hydrogenchloride / ethyl acetate / 0.75 h

3: dichloromethane; N,N-dimethyl-formamide; acetonitrile / 48 h / 20 °C

4: pyridine; silver trifluoromethanesulfonate / 2 h / 0 - 20 °C / Inert atmosphere

5: potassium fluoride; [2.2.2]cryptande / acetonitrile / 48 h / 80 °C

With pyridine; hydrogenchloride; potassium fluoride; silver trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine; [2.2.2]cryptande; In tert-Amyl alcohol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.ejmech.2012.04.011