6-ethylmethylamino-2-(4-fluorophenyl)quinoline

Base Information

Chemical Name:6-ethylmethylamino-2-(4-fluorophenyl)quinoline
CAS No.:1374107-55-7
Molecular Formula:C₁₈H₁₇FN₂
Molecular Weight:280.345
Hs Code.:

Synonyms:6-ethylmethylamino-2-(4-fluorophenyl)quinoline

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Chemical Property of 6-ethylmethylamino-2-(4-fluorophenyl)quinoline

Chemical Property:

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Technology Process of 6-ethylmethylamino-2-(4-fluorophenyl)quinoline

There total 6 articles about 6-ethylmethylamino-2-(4-fluorophenyl)quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1374109-13-3
C₁₆H₁₃FN₂

: 75-07-0,9002-91-9
acetaldehyde

: 1374107-55-7
6-ethylmethylamino-2-(4-fluorophenyl)quinoline

Guidance literature:: With 2-picoline borane complex; acetic acid; In methanol; at 20 ℃; for 16h; Cooling with ice;

Reference yield:

: 6-(tert-butoxycarbonyl)aminoquinoline

: 1374107-55-7
6-ethylmethylamino-2-(4-fluorophenyl)quinoline

Guidance literature:: Multi-step reaction with 6 steps

1.1: 3-chloro-benzenecarboperoxoic acid / methanol; chloroform / 16 h / 20 °C

2.1: potassium carbonate; p-toluenesulfonyl chloride / chloroform / 3.5 h / 20 °C / Reflux

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; 1,2-dimethoxyethane / 5.5 h / 80 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.08 h / Cooling with ice; Inert atmosphere

4.2: 0.17 h

5.1: trifluoroacetic acid / chloroform / 1 h / 20 °C / Cooling with ice

6.1: acetic acid; 2-picoline borane complex / methanol / 16 h / 20 °C / Cooling with ice

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2-picoline borane complex; sodium hydride; potassium carbonate; acetic acid; p-toluenesulfonyl chloride; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; In methanol; 1,2-dimethoxyethane; chloroform; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1374108-78-7
C₁₄H₁₅ClN₂O₂

: 1374107-55-7
6-ethylmethylamino-2-(4-fluorophenyl)quinoline

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; 1,2-dimethoxyethane / 5.5 h / 80 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.08 h / Cooling with ice; Inert atmosphere

2.2: 0.17 h

3.1: trifluoroacetic acid / chloroform / 1 h / 20 °C / Cooling with ice

4.1: acetic acid; 2-picoline borane complex / methanol / 16 h / 20 °C / Cooling with ice

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2-picoline borane complex; sodium hydride; potassium carbonate; acetic acid; trifluoroacetic acid; In methanol; 1,2-dimethoxyethane; chloroform; water; N,N-dimethyl-formamide; mineral oil;