5-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1-nitro-5H-thiopheno[3,4-c]pyrrole-4,6-dione

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Chemical Name:5-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1-nitro-5H-thiopheno[3,4-c]pyrrole-4,6-dione
CAS No.:1255908-80-5
Molecular Formula:C₁₈H₁₈N₂O₈S₂
Molecular Weight:454.482
Hs Code.:

Synonyms:5-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1-nitro-5H-thiopheno[3,4-c]pyrrole-4,6-dione

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Chemical Property of 5-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1-nitro-5H-thiopheno[3,4-c]pyrrole-4,6-dione

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Technology Process of 5-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1-nitro-5H-thiopheno[3,4-c]pyrrole-4,6-dione

There total 7 articles about 5-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1-nitro-5H-thiopheno[3,4-c]pyrrole-4,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 253168-94-4
2-(3-ethoxy-4-methoxyphenyl)-1-(methylsulfonyl)eth-2-ylamine

: 932032-16-1
4-nitrothiophene[3,4-c]furan-1,3-diketone

: 1255908-80-5
5-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1-nitro-5H-thiopheno[3,4-c]pyrrole-4,6-dione

Guidance literature:: 2-(3-ethoxy-4-methoxyphenyl)-1-(methylsulfonyl)eth-2-ylamine; 4-nitrothiophene[3,4-c]furan-1,3-diketone; In tetrahydrofuran; at 20 ℃;

With 1,1'-carbonyldiimidazole; In tetrahydrofuran; for 2h; Reflux;

Reference yield:

: 621-59-0
isovanillin

: 1255908-80-5
5-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1-nitro-5H-thiopheno[3,4-c]pyrrole-4,6-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C / Inert atmosphere

2.2: 20 °C / Cooling with salt-ice; Inert atmosphere

3.1: hydrogenchloride; water / diethyl ether / 0.5 h / 20 °C

3.2: pH 12 / Cooling with ice

4.1: tetrahydrofuran / 20 °C

4.2: 2 h / Reflux

With hydrogenchloride; n-butyllithium; water; potassium carbonate; In tetrahydrofuran; diethyl ether; hexane; N,N-dimethyl-formamide;

Reference yield:

: 18853-32-2
3,4-dicyanothiophene

: 1255908-80-5
5-(1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1-nitro-5H-thiopheno[3,4-c]pyrrole-4,6-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium hydroxide / ethylene glycol / 4 h

1.2: Cooling with ice

2.1: acetic anhydride / 3 h / Reflux

3.1: nitric acid / 0.5 h / 0 - 5 °C

4.1: acetic anhydride / 3 h / Reflux

5.1: tetrahydrofuran / 20 °C

5.2: 2 h / Reflux

With nitric acid; acetic anhydride; potassium hydroxide; In tetrahydrofuran; ethylene glycol;