2-(2-chloro-5-fluorophenyl)-5-[5-(2H-tetrazol-5-yl)isoxazol-3-yl]octahydropyrrolo[3,4-c]pyrrole

Base Information

Chemical Name:2-(2-chloro-5-fluorophenyl)-5-[5-(2H-tetrazol-5-yl)isoxazol-3-yl]octahydropyrrolo[3,4-c]pyrrole
CAS No.:1246749-88-1
Molecular Formula:C₁₆H₁₅ClFN₇O
Molecular Weight:375.793
Hs Code.:

Synonyms:2-(2-chloro-5-fluorophenyl)-5-[5-(2H-tetrazol-5-yl)isoxazol-3-yl]octahydropyrrolo[3,4-c]pyrrole

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Chemical Property of 2-(2-chloro-5-fluorophenyl)-5-[5-(2H-tetrazol-5-yl)isoxazol-3-yl]octahydropyrrolo[3,4-c]pyrrole

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Technology Process of 2-(2-chloro-5-fluorophenyl)-5-[5-(2H-tetrazol-5-yl)isoxazol-3-yl]octahydropyrrolo[3,4-c]pyrrole

There total 8 articles about 2-(2-chloro-5-fluorophenyl)-5-[5-(2H-tetrazol-5-yl)isoxazol-3-yl]octahydropyrrolo[3,4-c]pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1246749-87-0
3-[5-(2-chloro-5-fluorophenyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl]isoxazole-5-carbonitrile

: 1246749-88-1
2-(2-chloro-5-fluorophenyl)-5-[5-(2H-tetrazol-5-yl)isoxazol-3-yl]octahydropyrrolo[3,4-c]pyrrole

Guidance literature:: With sodium azide; ammonium chloride; In 1,4-dioxane; dimethyl sulfoxide; at 110 ℃; for 16h;

Reference yield:

: 1246749-87-0
3-[5-(2-chloro-5-fluorophenyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl]isoxazole-5-carbonitrile

: 1246749-88-1
C₁₆H₁₅ClFN₇O

Guidance literature:: With sodium azide; ammonium chloride; In 1,4-dioxane; dimethyl sulfoxide; at 110 ℃; for 16h;
DOI:10.1016/j.bmcl.2011.12.002

Reference yield:

: 1246749-86-9
3-[5-(2-chloro-5-fluorophenyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl]-4,5-dihydroisoxazole-5-carboxamide

: 1246749-88-1
C₁₆H₁₅ClFN₇O

Guidance literature:: Multi-step reaction with 3 steps

1: 1H-imidazole; iodine / toluene / 16 h / Reflux

2: triethylamine; trifluoroacetic anhydride / tetrahydrofuran / 1 h / 0 - 20 °C

3: sodium azide; ammonium chloride / 1,4-dioxane; dimethyl sulfoxide / 16 h / 110 °C

With 1H-imidazole; sodium azide; iodine; ammonium chloride; triethylamine; trifluoroacetic anhydride; In tetrahydrofuran; 1,4-dioxane; dimethyl sulfoxide; toluene;
DOI:10.1016/j.bmcl.2011.12.002