4-Chloro-3-fluoroiodobenzene

Base Information

• Chemical Name: 4-Chloro-3-fluoroiodobenzene
• CAS No.: 202982-67-0
• Molecular Formula: C6H3ClFI
• Molecular Weight: 256.446
• Hs Code.: 2903999090
• DSSTox Substance ID: DTXSID00371444
• Nikkaji Number: J983.320J
• Wikidata: Q72473609
• Mol file: 202982-67-0.mol

Synonyms:4-Chloro-3-fluoroiodobenzene;202982-67-0;1-chloro-2-fluoro-4-iodobenzene;3-fluoro-4-chloro iodo benzene;Benzene, 1-chloro-2-fluoro-4-iodo-;MFCD00042580;1-chloro-2-fluoro-4-iodo-benzene;3-fluoro-4-chloro iodobenzene;3-fluoro-4-chloro-iodobenzene;SCHEMBL1118567;DTXSID00371444;TD1131;AKOS009158087;CS-W004752;4-chloro-3-fluoroiodobenzene, AldrichCPR;DS-13374;SY030483;AM20030300;FT-0653551;EN300-1717262;A814409

Chemical Property of 4-Chloro-3-fluoroiodobenzene

Chemical Property:

• Appearance/Colour: light yellow liquid
• Refractive Index: 1.609
• Boiling Point: 221.7 °C at 760 mmHg
• Flash Point: 87.9 °C
• PSA: 0.00000
• Density: 2.008 g/cm³
• LogP: 3.08370
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• XLogP3: 3.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 255.89520
• Heavy Atom Count: 9
• Complexity: 99.1

Purity/Quality:

97% ^*data from raw suppliers

4-Chloro-3-fluoroiodobenzene 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi,Xn
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-36-22
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C=C1I)F)Cl

Technology Process of 4-Chloro-3-fluoroiodobenzene

There total 3 articles about 4-Chloro-3-fluoroiodobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,3-dichloro-2-fluorobenzene (2268-05-5) → 1-chloro-2-fluoro-4-iodo-benzene (202982-67-0)

Guidance literature:

Multi-step reaction with 2 steps

1: KNH₂ / liquid ammonia

2: (i) NaNO₂, aq. HCl, (ii) KI

With potassium amide; In ammonia;

DOI:10.1021/ja00734a027

Reference yield:

2,6-dichlorobenzenediazonium tetrafluoroborate → 1-chloro-2-fluoro-4-iodo-benzene (202982-67-0)

Guidance literature:

Multi-step reaction with 3 steps

1: (pyrolysis)

2: KNH₂ / liquid ammonia

3: (i) NaNO₂, aq. HCl, (ii) KI

With potassium amide; In ammonia;

DOI:10.1021/ja00734a027

Reference yield:

4-chloro-3-fluoroaniline (367-22-6) → 1-chloro-2-fluoro-4-iodo-benzene (202982-67-0)

Guidance literature:

Multistep reaction; (i) NaNO₂, aq. HCl, (ii) KI;

DOI:10.1021/ja00734a027

upstream raw materials:

4-chloro-3-fluoroaniline

1,3-dichloro-2-fluorobenzene

Downstream raw materials:

methyl (4-chloro-3-fluorophenyl)-(3,3,3-trifluoropropylsulfonyl)acetate

1-chloro-2-fluoro-4-(3-methoxyphenoxy)benzene