(1-(3-chloro-2-methylbenzyl)-6-morpholino-2-(trifluoromethyl)-1H-benzo[d]imidazol-4-yl)boronic acid

Base Information

Chemical Name:(1-(3-chloro-2-methylbenzyl)-6-morpholino-2-(trifluoromethyl)-1H-benzo[d]imidazol-4-yl)boronic acid
CAS No.:1443541-06-7
Molecular Formula:C₂₀H₂₀BClF₃N₃O₃
Molecular Weight:453.656
Hs Code.:

Synonyms:(1-(3-chloro-2-methylbenzyl)-6-morpholino-2-(trifluoromethyl)-1H-benzo[d]imidazol-4-yl)boronic acid

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Chemical Property of (1-(3-chloro-2-methylbenzyl)-6-morpholino-2-(trifluoromethyl)-1H-benzo[d]imidazol-4-yl)boronic acid

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Technology Process of (1-(3-chloro-2-methylbenzyl)-6-morpholino-2-(trifluoromethyl)-1H-benzo[d]imidazol-4-yl)boronic acid

There total 6 articles about (1-(3-chloro-2-methylbenzyl)-6-morpholino-2-(trifluoromethyl)-1H-benzo[d]imidazol-4-yl)boronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 121-43-7,63156-11-6
Trimethyl borate

: 1443541-42-1
4-(4-bromo-1-(3-chloro-2-methylbenzyl)-2-(trifluoromethyl)-1H-benzo[d]imidazol-6-yl)morpholine

: 1443541-06-7
(1-(3-chloro-2-methylbenzyl)-6-morpholino-2-(trifluoromethyl)-1H-benzo[d]imidazol-4-yl)boronic acid

Guidance literature:: Trimethyl borate; 4-(4-bromo-1-(3-chloro-2-methylbenzyl)-2-(trifluoromethyl)-1H-benzo[d]imidazol-6-yl)morpholine; With n-butyllithium; In tetrahydrofuran; at -78 - 20 ℃; for 1h; Inert atmosphere; Cooling with ice;

With methanol; ammonium acetate; In tetrahydrofuran;

Reference yield:

: 69399-60-6
3-Bromo-5-nitro-1,2-diaminobenzene

: 1443541-06-7
(1-(3-chloro-2-methylbenzyl)-6-morpholino-2-(trifluoromethyl)-1H-benzo[d]imidazol-4-yl)boronic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 17 h / 85 °C

2: potassium carbonate / N,N-dimethyl-formamide / 6 h / 90 °C

3: hydrogenchloride; tin(II) chloride dihdyrate / water; methanol / 0.5 h / 50 °C

4: sodium hydroxide; tetra-(n-butyl)ammonium iodide / water / 2 h / 110 °C

5: n-butyllithium / tetrahydrofuran / 1 h / -78 - 20 °C / Inert atmosphere; Cooling with ice

With hydrogenchloride; n-butyllithium; tin(II) chloride dihdyrate; tetra-(n-butyl)ammonium iodide; potassium carbonate; sodium hydroxide; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 6609-37-6
4-bromo-6-nitro-2-(trifluoromethyl)-1H-benzo[d]imidazole

: 1443541-06-7
(1-(3-chloro-2-methylbenzyl)-6-morpholino-2-(trifluoromethyl)-1H-benzo[d]imidazol-4-yl)boronic acid

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 6 h / 90 °C

2: hydrogenchloride; tin(II) chloride dihdyrate / water; methanol / 0.5 h / 50 °C

3: sodium hydroxide; tetra-(n-butyl)ammonium iodide / water / 2 h / 110 °C

4: n-butyllithium / tetrahydrofuran / 1 h / -78 - 20 °C / Inert atmosphere; Cooling with ice

With hydrogenchloride; n-butyllithium; tin(II) chloride dihdyrate; tetra-(n-butyl)ammonium iodide; potassium carbonate; sodium hydroxide; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;