1-(hydroxymethyl)-2-(4-chloro-3-sulfamoylbenzamido)isoindoline

Base Information

• Chemical Name: 1-(hydroxymethyl)-2-(4-chloro-3-sulfamoylbenzamido)isoindoline
• CAS No.: 77856-15-6
• Molecular Formula: C₁₆H₁₆ClN₃O₄S
• Molecular Weight: 381.84
• Mol file: 77856-15-6.mol

Synonyms:1-(hydroxymethyl)-2-(4-chloro-3-sulfamoylbenzamido)isoindoline

Chemical Property of 1-(hydroxymethyl)-2-(4-chloro-3-sulfamoylbenzamido)isoindoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 1-(hydroxymethyl)-2-(4-chloro-3-sulfamoylbenzamido)isoindoline

There total 4 articles about 1-(hydroxymethyl)-2-(4-chloro-3-sulfamoylbenzamido)isoindoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

1-carbomethoxy-2-(4-chloro-3-sulfamoylbenzamido)isoindoline (77856-14-5) → 1-(hydroxymethyl)-2-(4-chloro-3-sulfamoylbenzamido)isoindoline (77856-15-6)

Guidance literature:

With lithium borohydride; In tetrahydrofuran; for 2h; Heating;

DOI:10.1021/jm00140a018

Reference yield:

methyl 2-bromomethyl-α-bromophenylacetate (56365-70-9) → 1-(hydroxymethyl)-2-(4-chloro-3-sulfamoylbenzamido)isoindoline (77856-15-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 81 percent / triethylamine / dimethylformamide / 3 h / Ambient temperature

2: 76 percent / HCl / methanol / 1 h

3: 70 percent / triethylamine / tetrahydrofuran / 20 h / Ambient temperature

4: 75 percent / LiBH₄ / tetrahydrofuran / 2 h / Heating

With hydrogenchloride; lithium borohydride; triethylamine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00140a018

Reference yield:

1-carbomethoxy-2-<(tert-butyloxycarbonyl)amino>isoindoline (77856-12-3) → 1-(hydroxymethyl)-2-(4-chloro-3-sulfamoylbenzamido)isoindoline (77856-15-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 76 percent / HCl / methanol / 1 h

2: 70 percent / triethylamine / tetrahydrofuran / 20 h / Ambient temperature

3: 75 percent / LiBH₄ / tetrahydrofuran / 2 h / Heating

With hydrogenchloride; lithium borohydride; triethylamine; In tetrahydrofuran; methanol;

DOI:10.1021/jm00140a018

upstream raw materials:

1-carbomethoxy-2-(4-chloro-3-sulfamoylbenzamido)isoindoline

methyl 2-bromomethyl-α-bromophenylacetate

1-carbomethoxy-2-<(tert-butyloxycarbonyl)amino>isoindoline

1-carbomethoxy-2-aminoisoindoline hydrochloride