benzyl 1-[2,3,6-O-tris(methoxymethylene)-4,5-O-bis(dibenzoxylphosphoryl)-myo-inositol]-4-(sn-3,4-O-dioctanoyl-1-fluoro-1-buten-1-yl)phosphonate

Base Information

Chemical Name:benzyl 1-[2,3,6-O-tris(methoxymethylene)-4,5-O-bis(dibenzoxylphosphoryl)-myo-inositol]-4-(sn-3,4-O-dioctanoyl-1-fluoro-1-buten-1-yl)phosphonate
CAS No.:888472-82-0
Molecular Formula:C₆₇H₉₀FO₂₁P₃
Molecular Weight:1343.36
Hs Code.:

Synonyms:benzyl 1-[2,3,6-O-tris(methoxymethylene)-4,5-O-bis(dibenzoxylphosphoryl)-myo-inositol]-4-(sn-3,4-O-dioctanoyl-1-fluoro-1-buten-1-yl)phosphonate

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Chemical Property of benzyl 1-[2,3,6-O-tris(methoxymethylene)-4,5-O-bis(dibenzoxylphosphoryl)-myo-inositol]-4-(sn-3,4-O-dioctanoyl-1-fluoro-1-buten-1-yl)phosphonate

Chemical Property:

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Technology Process of benzyl 1-[2,3,6-O-tris(methoxymethylene)-4,5-O-bis(dibenzoxylphosphoryl)-myo-inositol]-4-(sn-3,4-O-dioctanoyl-1-fluoro-1-buten-1-yl)phosphonate

There total 5 articles about benzyl 1-[2,3,6-O-tris(methoxymethylene)-4,5-O-bis(dibenzoxylphosphoryl)-myo-inositol]-4-(sn-3,4-O-dioctanoyl-1-fluoro-1-buten-1-yl)phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 888472-80-8
benzyl 1-[2,3,6-O-tris(methoxymethylene)-4,5-O-bis(dibenzoxylphosphoryl)-myo-inositol]-4-(sn-3,4-dihydroxy-1-fluoro-1-buten-1-yl)phosphonate

: 124-07-2
Octanoic acid

: 888472-82-0
benzyl 1-[2,3,6-O-tris(methoxymethylene)-4,5-O-bis(dibenzoxylphosphoryl)-myo-inositol]-4-(sn-3,4-O-dioctanoyl-1-fluoro-1-buten-1-yl)phosphonate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;
DOI:10.1021/ja060621d

Reference yield:

: 888472-78-4
C₄₇H₅₇O₁₇P₃

: 888472-82-0
benzyl 1-[2,3,6-O-tris(methoxymethylene)-4,5-O-bis(dibenzoxylphosphoryl)-myo-inositol]-4-(sn-3,4-O-dioctanoyl-1-fluoro-1-buten-1-yl)phosphonate

Guidance literature:: Multi-step reaction with 3 steps

1: 62 percent / Pd(OAc)2; dppf; propylene oxide / tetrahydrofuran / 10 h / 70 °C

2: 86 percent / TFA; water / tetrahydrofuran / 1 h / 0 °C

3: 68 percent / EDCI; DMAP / CH₂Cl₂ / 20 °C

With dmap; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; methyloxirane; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja060621d

Reference yield:

: Phosphoric acid dibenzyl ester (1R,2R,3S,4R,5R,6S)-4-(benzyloxy-diisopropylamino-phosphanyloxy)-2-(bis-benzyloxy-phosphoryloxy)-3,5,6-tris-methoxymethoxy-cyclohexyl ester

: 888472-82-0
benzyl 1-[2,3,6-O-tris(methoxymethylene)-4,5-O-bis(dibenzoxylphosphoryl)-myo-inositol]-4-(sn-3,4-O-dioctanoyl-1-fluoro-1-buten-1-yl)phosphonate

Guidance literature:: Multi-step reaction with 4 steps

1: 90 mg / water; 1H-tetrazole / CH₂Cl₂ / 1 h / 20 °C

2: 62 percent / Pd(OAc)2; dppf; propylene oxide / tetrahydrofuran / 10 h / 70 °C

3: 86 percent / TFA; water / tetrahydrofuran / 1 h / 0 °C

4: 68 percent / EDCI; DMAP / CH₂Cl₂ / 20 °C

With 1H-tetrazole; dmap; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; methyloxirane; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja060621d