4-Chloro-2-fluorobenzylamine

Base Information

Chemical Name:4-Chloro-2-fluorobenzylamine
CAS No.:72235-57-5
Molecular Formula:C7H7ClFN
Molecular Weight:159.591
Hs Code.:2921499090
DSSTox Substance ID:DTXSID60369286
Nikkaji Number:J2.323.055K
Wikidata:Q72450681
Mol file:72235-57-5.mol

Synonyms:4-Chloro-2-fluorobenzylamine;72235-57-5;(4-chloro-2-fluorophenyl)methanamine;4-CHLORO-2-FLUOROBENZYL AMINE;Benzenemethanamine, 4-chloro-2-fluoro-;Benzenemethanamine,4-chloro-2-fluoro-;2-fluoro-4-chlorobenzylamine;SCHEMBL992833;TIMTEC-BB SBB003972;DTXSID60369286;ODMMHGMIZYLHNN-UHFFFAOYSA-N;CK2426;MFCD06212852;AKOS000169781;SB76555;4-Chloro-2-fluorobenzylamine, AldrichCPR;AC-25945;AS-45904;CS-0094798;A19821;J-514941

Suppliers and Price of 4-Chloro-2-fluorobenzylamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

SynQuest Laboratories
4-Chloro-2-fluorobenzylamine
5 g
$ 162.00

SynQuest Laboratories
4-Chloro-2-fluorobenzylamine
10 g
$ 287.00

Matrix Scientific
4-Chloro-2-fluorobenzylamine
5g
$ 240.00

Matrix Scientific
4-Chloro-2-fluorobenzylamine
10g
$ 424.00

Crysdot
(4-Chloro-2-fluorophenyl)methanamine 97%
1g
$ 45.00

Crysdot
(4-Chloro-2-fluorophenyl)methanamine 97%
5g
$ 160.00

Crysdot
(4-Chloro-2-fluorophenyl)methanamine 97%
25g
$ 350.00

Biosynth Carbosynth
4-Chloro-2-fluorobenzylamine
25 g
$ 520.00

Biosynth Carbosynth
4-Chloro-2-fluorobenzylamine
10 g
$ 300.00

Biosynth Carbosynth
4-Chloro-2-fluorobenzylamine
2 g
$ 125.00

Total 28 raw suppliers

Chemical Property of 4-Chloro-2-fluorobenzylamine

Chemical Property:

Boiling Point:211.1 °C at 760 mmHg
PKA:8.43±0.10(Predicted)
Flash Point:81.5 °C
PSA：26.02000
Density:1.27 g/cm³
LogP:2.63810
Storage Temp.:2-8°C(protect from light)
Sensitive.:Air Sensitive
XLogP3:1.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:159.0251051
Heavy Atom Count:10
Complexity:110

Purity/Quality:

97% ^*data from raw suppliers

4-Chloro-2-fluorobenzylamine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=C(C=C1Cl)F)CN

Technology Process of 4-Chloro-2-fluorobenzylamine

There total 3 articles about 4-Chloro-2-fluorobenzylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 536761-10-1
N-(4-chloro-2-fluoro-benzyl)phthalimide

: 72235-57-5
(4-chloro-2-fluorophenyl)methanamine

Guidance literature:: With hydrazine; In tetrahydrofuran; at 80 ℃; for 1h;
DOI:10.1016/j.bmcl.2006.04.009

Reference yield:

: 61072-56-8
4-chloro-2-fluorobenzaldehyde

: 72235-57-5
(4-chloro-2-fluorophenyl)methanamine

Guidance literature:: Multi-step reaction with 3 steps

1: NaBH₄ / tetrahydrofuran / 1 h / 20 °C

2: Ph₃P; DIAD / tetrahydrofuran / 3 h / 20 °C

3: hydrazine / tetrahydrofuran / 1 h / 80 °C

With sodium tetrahydroborate; di-isopropyl azodicarboxylate; triphenylphosphine; hydrazine; In tetrahydrofuran; 2: Mitsunobu reaction;
DOI:10.1016/j.bmcl.2006.04.009

Reference yield:

: 56456-49-6
(4-chloro-2-fluorophenyl)methanol

: 72235-57-5
(4-chloro-2-fluorophenyl)methanamine

Guidance literature:: Multi-step reaction with 2 steps

1: Ph₃P; DIAD / tetrahydrofuran / 3 h / 20 °C

2: hydrazine / tetrahydrofuran / 1 h / 80 °C

With di-isopropyl azodicarboxylate; triphenylphosphine; hydrazine; In tetrahydrofuran; 1: Mitsunobu reaction;
DOI:10.1016/j.bmcl.2006.04.009