isopropyl 2-(4-(2-(4-chlorobenzamido)ethyl)phenoxy)-2-methylpropanoate

Base Information

• Chemical Name: isopropyl 2-(4-(2-(4-chlorobenzamido)ethyl)phenoxy)-2-methylpropanoate
• CAS No.: 153758-85-1
• Molecular Formula: C₂₂H₂₆ClNO₄
• Molecular Weight: 403.906
• Mol file: 153758-85-1.mol

Synonyms:isopropyl 2-(4-(2-(4-chlorobenzamido)ethyl)phenoxy)-2-methylpropanoate

Chemical Property of isopropyl 2-(4-(2-(4-chlorobenzamido)ethyl)phenoxy)-2-methylpropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of isopropyl 2-(4-(2-(4-chlorobenzamido)ethyl)phenoxy)-2-methylpropanoate

There total 3 articles about isopropyl 2-(4-(2-(4-chlorobenzamido)ethyl)phenoxy)-2-methylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

isopropyl 2-bromo-2?methylpropanoate (51368-55-9) + 4-chloro-N-(4-hydroxyphenethyl)benzamide (41859-57-8) → isopropyl 2-(4-(2-(4-chlorobenzamido)ethyl)phenoxy)-2-methylpropanoate (153758-85-1)

Guidance literature:

With potassium carbonate; In acetonitrile; at 85 ℃;

DOI:10.1021/acs.orglett.1c03993

Reference yield:

tyrosamine (51-67-2) → isopropyl 2-(4-(2-(4-chlorobenzamido)ethyl)phenoxy)-2-methylpropanoate (153758-85-1)

Guidance literature:

Multi-step reaction with 2 steps

1: acetonitrile / 50 °C

2: potassium carbonate / acetonitrile / 85 °C

With potassium carbonate; In acetonitrile;

DOI:10.1021/acs.orglett.1c03993

Reference yield:

C13H7BrClN3O2 → isopropyl 2-(4-(2-(4-chlorobenzamido)ethyl)phenoxy)-2-methylpropanoate (153758-85-1)

Guidance literature:

Multi-step reaction with 2 steps

1: acetonitrile / 50 °C

2: potassium carbonate / acetonitrile / 85 °C

With potassium carbonate; In acetonitrile;

DOI:10.1021/acs.orglett.1c03993

upstream raw materials:

isopropyl 2-bromo-2?methylpropanoate

4-chloro-N-(4-hydroxyphenethyl)benzamide

tyrosamine

Downstream raw materials:

bezafibrate

Refernces