N^α-tert-butyloxycarbonyl-2'-isopropyl-6'-methyl-L-phenylalanyl-L-phenylalanylamide

Base Information

• Chemical Name: N^α-tert-butyloxycarbonyl-2'-isopropyl-6'-methyl-L-phenylalanyl-L-phenylalanylamide
• CAS No.: 943726-75-8
• Molecular Formula: C₂₇H₃₇N₃O₄
• Molecular Weight: 467.608

Synonyms:N^α-tert-butyloxycarbonyl-2'-isopropyl-6'-methyl-L-phenylalanyl-L-phenylalanylamide

Chemical Property of N^α-tert-butyloxycarbonyl-2'-isopropyl-6'-methyl-L-phenylalanyl-L-phenylalanylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N^α-tert-butyloxycarbonyl-2'-isopropyl-6'-methyl-L-phenylalanyl-L-phenylalanylamide

There total 3 articles about N^α-tert-butyloxycarbonyl-2'-isopropyl-6'-methyl-L-phenylalanyl-L-phenylalanylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

Nα-tert-butyloxycarbonyl-2'-isopropyl-6'-methyl-L-phenylalanine (943726-69-0) + (S)-2-amino-3-phenylpropionamide hydrochloride (65864-22-4) → Nα-tert-butyloxycarbonyl-2'-isopropyl-6'-methyl-L-phenylalanyl-L-phenylalanylamide (943726-75-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

DOI:10.1021/jm061238m

Reference yield:

2'-isopropyl-6'-methyl-L-phenylalanine → Nα-tert-butyloxycarbonyl-2'-isopropyl-6'-methyl-L-phenylalanyl-L-phenylalanylamide (943726-75-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 90.3 percent / triethylamine / dioxane; H₂O / 2 h / 20 °C

2: 93 percent / diisopropylethylamine; benzotriazol-1-yloxytrispyrrolidinophosphonium*PF₆ / dimethylformamide / 4 h / 20 °C

With triethylamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; water; N,N-dimethyl-formamide;

DOI:10.1021/jm061238m

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → Nα-tert-butyloxycarbonyl-2'-isopropyl-6'-methyl-L-phenylalanyl-L-phenylalanylamide (943726-75-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 90.3 percent / triethylamine / dioxane; H₂O / 2 h / 20 °C

2: 93 percent / diisopropylethylamine; benzotriazol-1-yloxytrispyrrolidinophosphonium*PF₆ / dimethylformamide / 4 h / 20 °C

With triethylamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; water; N,N-dimethyl-formamide;

DOI:10.1021/jm061238m

upstream raw materials:

N^α-tert-butyloxycarbonyl-2'-isopropyl-6'-methyl-L-phenylalanine

(S)-2-amino-3-phenylpropionamide hydrochloride

di-tert-butyl dicarbonate

Downstream raw materials:

N^α-tert-butyloxycarbonyl-2',6'-dimethyl-L-tyrosyl-L-prolyl-2'-isopropyl-6'-methyl-L-phenylalanyl-L-phenylalanylamide

N^α-tert-butyloxycarbonyl-L-tyrosyl-L-prolyl-2'-isopropyl-6'-methyl-L-phenylalanyl-L-phenylalanylamide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 943726-75-8 N^α-tert-butyloxycarbonyl-2'-isopropyl-6'-methyl-L-phenylalanyl-L-phenylalanylamide

Send

Send

Metric Ton KG G Pound L ML

Send

Send