5-<4-(6-tert-butoxycarbonylaminohexanoylamino)benzyl>thiazolidine-2,4-dione

Base Information

Chemical Name:5-<4-(6-tert-butoxycarbonylaminohexanoylamino)benzyl>thiazolidine-2,4-dione
CAS No.:85010-81-7
Molecular Formula:C₂₁H₂₉N₃O₅S
Molecular Weight:435.544
Hs Code.:

Synonyms:5-<4-(6-tert-butoxycarbonylaminohexanoylamino)benzyl>thiazolidine-2,4-dione

Suppliers and Price of 5-<4-(6-tert-butoxycarbonylaminohexanoylamino)benzyl>thiazolidine-2,4-dione

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Chemical Property of 5-<4-(6-tert-butoxycarbonylaminohexanoylamino)benzyl>thiazolidine-2,4-dione

Chemical Property:

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Technology Process of 5-<4-(6-tert-butoxycarbonylaminohexanoylamino)benzyl>thiazolidine-2,4-dione

There total 4 articles about 5-<4-(6-tert-butoxycarbonylaminohexanoylamino)benzyl>thiazolidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6404-29-1
6-(tert-butoxycarbonylamino)hexanoic acid

: 85002-36-4
5-(4-amino-benzyl)-thiazolidin-2,4-dione

: 85010-81-7
5-<4-(6-tert-butoxycarbonylaminohexanoylamino)benzyl>thiazolidine-2,4-dione

Guidance literature:: With chloroformic acid ethyl ester; triethylamine; Yield given. Multistep reaction; 1.) CH₂Cl₂, ice-cooling, 15 min; 2.) CH₂Cl₂, -10 deg C, 30 min, room temp., 1 h;
DOI:10.1248/cpb.30.3580

Reference yield:

: 57460-34-1
ethyl 2-chloro-3-(4-nitrophenyl)propionate

: 85010-81-7
5-<4-(6-tert-butoxycarbonylaminohexanoylamino)benzyl>thiazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 2.) 2N HCl / 1.) sulfolane, 120 deg C, 5 h; 2.) sulfolane, 100 deg C, 15 h

2: 88.6 percent / hydrogen / 10percent Pd-C / methanol; ethyl acetate / 760 Torr / Ambient temperature

3: 1.) Et₃N, ethyl chloroformate; 2.) Et₃N / 1.) CH₂Cl₂, ice-cooling, 15 min; 2.) CH₂Cl₂, -10 deg C, 30 min, room temp., 1 h

With hydrogenchloride; hydrogen; chloroformic acid ethyl ester; triethylamine; palladium on activated charcoal; In methanol; ethyl acetate;
DOI:10.1248/cpb.30.3580

Reference yield:

: 100-01-6,104810-17-5
4-nitro-aniline

: 85010-81-7
5-<4-(6-tert-butoxycarbonylaminohexanoylamino)benzyl>thiazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaNO₂, conc. HCl, 2.) Cu₂O / 1.) acetone, water, 5 deg C, 30 min, 2.) acetone, water, 10 deg C

2: 2.) 2N HCl / 1.) sulfolane, 120 deg C, 5 h; 2.) sulfolane, 100 deg C, 15 h

3: 88.6 percent / hydrogen / 10percent Pd-C / methanol; ethyl acetate / 760 Torr / Ambient temperature

4: 1.) Et₃N, ethyl chloroformate; 2.) Et₃N / 1.) CH₂Cl₂, ice-cooling, 15 min; 2.) CH₂Cl₂, -10 deg C, 30 min, room temp., 1 h

With copper(I) oxide; hydrogenchloride; hydrogen; chloroformic acid ethyl ester; triethylamine; sodium nitrite; palladium on activated charcoal; In methanol; ethyl acetate;
DOI:10.1248/cpb.30.3580