rac-ethyl 8-[1-(2,6-difluorophenyl)ethoxy]-2,6-dimethylimidazo[1,2-a]pyridine-3-carboxylate

Base Information

Chemical Name:rac-ethyl 8-[1-(2,6-difluorophenyl)ethoxy]-2,6-dimethylimidazo[1,2-a]pyridine-3-carboxylate
CAS No.:1609166-29-1
Molecular Formula:C₂₀H₂₀F₂N₂O₃
Molecular Weight:374.387
Hs Code.:

Synonyms:rac-ethyl 8-[1-(2,6-difluorophenyl)ethoxy]-2,6-dimethylimidazo[1,2-a]pyridine-3-carboxylate

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Chemical Property of rac-ethyl 8-[1-(2,6-difluorophenyl)ethoxy]-2,6-dimethylimidazo[1,2-a]pyridine-3-carboxylate

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Technology Process of rac-ethyl 8-[1-(2,6-difluorophenyl)ethoxy]-2,6-dimethylimidazo[1,2-a]pyridine-3-carboxylate

There total 5 articles about rac-ethyl 8-[1-(2,6-difluorophenyl)ethoxy]-2,6-dimethylimidazo[1,2-a]pyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.8%

: 1609082-35-0
ethyl 8-hydroxy-2,6-dimethylimidazo[1,2-a]pyridine-3-carboxylate

: 87327-65-9,126534-38-1
2,6-Difluoro-alpha-methylbenzyl alcohol

: 1609166-29-1
rac-ethyl 8-[1-(2,6-difluorophenyl)ethoxy]-2,6-dimethylimidazo[1,2-a]pyridine-3-carboxylate

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 3h;

Reference yield:

: 754230-78-9
3-(benzyloxy)-5-bromopyridine-2-amine

: 1609166-29-1
rac-ethyl 8-[1-(2,6-difluorophenyl)ethoxy]-2,6-dimethylimidazo[1,2-a]pyridine-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: ethanol / 72 h / Inert atmosphere; Reflux; Molecular sieve

2: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 8 h / Inert atmosphere; Reflux

3: hydrogen; palladium 10% on activated carbon / ethanol; dichloromethane / 20 °C / 760.05 Torr / Inert atmosphere

4: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 3 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; di-isopropyl azodicarboxylate; palladium 10% on activated carbon; hydrogen; potassium carbonate; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane;

Reference yield:

: 1609082-33-8
ethyl 8-(benzyloxy)-6-bromo-2-methylimidazo[1,2-a]pyridine-3-carboxylate

: 1609166-29-1
rac-ethyl 8-[1-(2,6-difluorophenyl)ethoxy]-2,6-dimethylimidazo[1,2-a]pyridine-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 8 h / Inert atmosphere; Reflux

2: hydrogen; palladium 10% on activated carbon / ethanol; dichloromethane / 20 °C / 760.05 Torr / Inert atmosphere

3: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 3 h / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; di-isopropyl azodicarboxylate; palladium 10% on activated carbon; hydrogen; potassium carbonate; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane;