(cis)-4-(methoxycarbonyl)-2-oxo-3-[[(phenylmethoxy)carbonyl]amino]-1-azetidine

Base Information

Chemical Name:(cis)-4-(methoxycarbonyl)-2-oxo-3-[[(phenylmethoxy)carbonyl]amino]-1-azetidine
CAS No.:122741-47-3
Molecular Formula:C₁₃H₁₄N₂O₅
Molecular Weight:278.265
Hs Code.:

Synonyms:(cis)-4-(methoxycarbonyl)-2-oxo-3-[[(phenylmethoxy)carbonyl]amino]-1-azetidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (cis)-4-(methoxycarbonyl)-2-oxo-3-[[(phenylmethoxy)carbonyl]amino]-1-azetidine

Chemical Property:

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Technology Process of (cis)-4-(methoxycarbonyl)-2-oxo-3-[[(phenylmethoxy)carbonyl]amino]-1-azetidine

There total 7 articles about (cis)-4-(methoxycarbonyl)-2-oxo-3-[[(phenylmethoxy)carbonyl]amino]-1-azetidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 83169-55-5,84187-45-1,88792-18-1,88792-19-2,90192-18-0,97591-37-2
trans-3-benzyloxycarbonylamino-1-(2,4-dimethoxybenzyl)-4-methoxycarbonyl-2-azetidinone

: 80542-47-8,84186-91-4,84486-22-6,88792-20-5,98675-57-1,122741-47-3
trans-3-benzyloxycarbonylamino-4-methoxycarbonyl-2-azetidinone

Guidance literature:: With dipotassium hydrogenphosphate; dipotassium peroxodisulfate; In water; acetonitrile; for 2h; Heating;
DOI:10.1248/cpb.32.2646

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 80542-47-8,84186-91-4,84486-22-6,88792-20-5,98675-57-1,122741-47-3
trans-3-benzyloxycarbonylamino-4-methoxycarbonyl-2-azetidinone

Guidance literature:: Multi-step reaction with 2 steps

1: propylene oxide / CH₂Cl₂ / 1.5 h / Ambient temperature

2: 70 percent / <1.6 molar equiv. K₂S₂O₈, K₂HPO₄ / acetonitrile; H₂O / 2 h / Heating

With dipotassium hydrogenphosphate; dipotassium peroxodisulfate; methyloxirane; In dichloromethane; water; acetonitrile;
DOI:10.1248/cpb.32.2646

Reference yield:

: 92973-52-9
methyl N-(2,4-dimethoxybenzyl)-N-(phthalimidoacetyl)immonioacetate chloride

: 80542-47-8,84186-91-4,84486-22-6,88792-20-5,98675-57-1,122741-47-3
trans-3-benzyloxycarbonylamino-4-methoxycarbonyl-2-azetidinone

Guidance literature:: Multi-step reaction with 4 steps

1: 10 percent / 1,8-diazabicyclo<5.4.0>-7-undecene / CH₂Cl₂ / 5 h / Ambient temperature

2: methylhydrazine / CH₂Cl₂

3: propylene oxide / CH₂Cl₂ / 1.5 h / Ambient temperature

4: 70 percent / <1.6 molar equiv. K₂S₂O₈, K₂HPO₄ / acetonitrile; H₂O / 2 h / Heating

With dipotassium hydrogenphosphate; dipotassium peroxodisulfate; 1,8-diazabicyclo[5.4.0]undec-7-ene; methylhydrazine; methyloxirane; In dichloromethane; water; acetonitrile;
DOI:10.1248/cpb.32.2646