(1SR,3SR,5RS,6RS,7RS)-6-bromo-3-(4-methoxyphenyl)-7-propyl-2,4-dithiabicyclo<3.2.1>octane

Base Information

Chemical Name:(1SR,3SR,5RS,6RS,7RS)-6-bromo-3-(4-methoxyphenyl)-7-propyl-2,4-dithiabicyclo<3.2.1>octane
CAS No.:106470-21-7
Molecular Formula:C₁₆H₂₁BrOS₂
Molecular Weight:373.378
Hs Code.:

Synonyms:(1SR,3SR,5RS,6RS,7RS)-6-bromo-3-(4-methoxyphenyl)-7-propyl-2,4-dithiabicyclo<3.2.1>octane

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Chemical Property of (1SR,3SR,5RS,6RS,7RS)-6-bromo-3-(4-methoxyphenyl)-7-propyl-2,4-dithiabicyclo<3.2.1>octane

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Technology Process of (1SR,3SR,5RS,6RS,7RS)-6-bromo-3-(4-methoxyphenyl)-7-propyl-2,4-dithiabicyclo<3.2.1>octane

There total 11 articles about (1SR,3SR,5RS,6RS,7RS)-6-bromo-3-(4-methoxyphenyl)-7-propyl-2,4-dithiabicyclo<3.2.1>octane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 106470-20-6
(1SR,3SR,5RS,6RS,7RS)-6-<(methanesulfonyl)oxy>-3-(4-methoxyphenyl)-7-propyl-2,4-dithiabicyclo<3.2.1>octane

: 106470-21-7
(1SR,3SR,5RS,6RS,7RS)-6-bromo-3-(4-methoxyphenyl)-7-propyl-2,4-dithiabicyclo<3.2.1>octane

Guidance literature:: With lithium bromide; In 1,2-dimethoxyethane; at 62 ℃; for 0.5h;
DOI:10.1021/jo00381a027

Reference yield:

: 20476-33-9
1α,4α-dibenzyloxy-2α,3α-epoxycyclopentane

: 106470-21-7
(1SR,3SR,5RS,6RS,7RS)-6-bromo-3-(4-methoxyphenyl)-7-propyl-2,4-dithiabicyclo<3.2.1>octane

Guidance literature:: Multi-step reaction with 11 steps

1: 98.6 percent / diethyl ether / 1.) -78 deg C, 1.5 h, 2.) from -78 deg C to -30 deg C, 2 h

2: 100 percent / N,N-diethylaniline / CH₂Cl₂ / 22 h / 22 °C

3: Na, ethanol / diethyl ether; liquid ammonia / 1 h / -78 °C

4: 100 percent / pyridine / 120 h / 0 °C

5: 100 percent / p-toluenesulfonic acid / methanol / 4 h / 22 °C

6: 92 percent / H₂ / 5percent Pd/C / ethanol; ethyl acetate / 9 h / 22 °C

7: 58 percent / dimethylformamide / 0.6 h / 84 °C

8: 4.6percent methanolic HCl / 4 h / 55 °C

9: 74 percent / BF₃*OEt₂ / CHCl₃ / 2 h / 22 °C

10: 100 percent / triethylamine / CH₂Cl₂ / 0.5 h / 0 °C

11: 60 percent / LiBr / 1,2-dimethoxy-ethane / 0.5 h / 62 °C

With pyridine; hydrogenchloride; ethanol; boron trifluoride diethyl etherate; hydrogen; sodium; toluene-4-sulfonic acid; triethylamine; N,N-diethylaniline; lithium bromide; palladium on activated charcoal; In methanol; 1,2-dimethoxyethane; diethyl ether; ethanol; dichloromethane; chloroform; ammonia; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jo00381a027

Reference yield:

: 106470-14-8,106565-09-7
(1RS,2SR,3RS,4SR)-3-(2-propenyl)-1,2,4-cyclopentanetriol 2-O-ethoxyethyl ether

: 106470-21-7
(1SR,3SR,5RS,6RS,7RS)-6-bromo-3-(4-methoxyphenyl)-7-propyl-2,4-dithiabicyclo<3.2.1>octane

Guidance literature:: Multi-step reaction with 8 steps

1: 100 percent / pyridine / 120 h / 0 °C

2: 100 percent / p-toluenesulfonic acid / methanol / 4 h / 22 °C

3: 92 percent / H₂ / 5percent Pd/C / ethanol; ethyl acetate / 9 h / 22 °C

4: 58 percent / dimethylformamide / 0.6 h / 84 °C

5: 4.6percent methanolic HCl / 4 h / 55 °C

6: 74 percent / BF₃*OEt₂ / CHCl₃ / 2 h / 22 °C

7: 100 percent / triethylamine / CH₂Cl₂ / 0.5 h / 0 °C

8: 60 percent / LiBr / 1,2-dimethoxy-ethane / 0.5 h / 62 °C

With pyridine; hydrogenchloride; boron trifluoride diethyl etherate; hydrogen; toluene-4-sulfonic acid; triethylamine; lithium bromide; palladium on activated charcoal; In methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; chloroform; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jo00381a027